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Circulation, Vol 56, 1103-1107, Copyright © 1977 by American Heart Association

ARTICLES

Familial congenital complete heart block and maternal systemic lupus erythematosis

RB Winkler, AH Nora and JJ Nora

A family is reported in which two siblings had congenital complete heart block with resultant congestive heart failure, the father and paternal grandfather show adult-onset conduction defects, and the mother has systemic lupus erythematosis. The interaction of heredity and environment is discussed in this context. A review of the literature on familial complete heart block suggests that so-called pure congenital-onset familial heart block, originally felt to be genetic, may in fact have an important enivronmental component, specifically related to ongoing maternal factors such as systemic lupus erythematosis.

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