Circulation, Vol 56, 944-950, Copyright © 1977 by American Heart Association
JW Kennedy, J Doces and DK Stewart
Twenty-four patients with aortic valve disease were studied before and
19+/-12 months following valve replacement with a well functioning
prosthesis. Biplane left ventricular angiography and pressures were
utilized to determine end-diastolic volume/m2 (EDV), end-systolic volume/m2
(ESV), ejection fraction (EF), left ventricular mass/m2 (LVM) and stroke
work (SW). There were nine patients with aortic stenosis (AS), ten patients
with combined stenosis and regurgitation (AS-AR), and five patients with
aortic regurgitation (AR). Following surgery, patients with regurgitation
preoperatively showed marked regression in EDV and ESV. All groups
demonstrated regression in LVM. Fifteen patients with a normal EF
preoperatively (65+/-11%) had no change after surgery; the nine patients
with a low EF before surgery (38+/-8%) had a normal EF after surgery
(60+/-16%). We conclude that left ventricular dilatation, hypertrophy, and
reduced left ventricular pump function are largely reversible after
successful aortic valve replacement.
ARTICLES
Left ventricular function before and following aortic valve replacement
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