Circulation, Vol 56, 985-989, Copyright © 1977 by American Heart Association
JA Udall and MH Ellestad
Follow-up data on future coronary events was collected on 6,500 patients
who had undergone stress testing; 1,327 of these exhibited ventricular
premature contractions (VPCs) associated with one or more phases of
treadmill stress testing (TSTs). Eighty-three percent of all patients
tested had known or suspected cardiovascular disease. The annual incidence
of new coronary events (myocardial infarction, angina, cardiac death)
during a five year follow-up was 1.7% among 1,067 patients without VPCs or
ischemic ST changes, 6.4% in 758 patients with VPCs alone, 9.5% among 609
patients with ischemic ST changes alone and 11.4% in 569 patients with VPCs
plus ischemic ST changes. The significance of VPCs associated with the TSTs
rests largely upon the clinical status of the persons tested. VPCs observed
among patients referred for TSTs for the evaluation of known or suspected
cardiovascular disease, with or without ischemic ST abnormalities,
represent a definite risk factor for future coronary events.
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Predictive implications of ventricular premature contractions associated with treadmill stress testing
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