This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sutton, M. G. Articles by Guiliani, E. R. Search for Related Content PubMed PubMed Citation Articles by Sutton, M. G. Articles by Guiliani, E. R.

Circulation, Vol 57, 512-520, Copyright © 1978 by American Heart Association

ARTICLES

Echocardiographic assessment of left ventricular filling and septal and posterior wall dynamics in idiopathic hypertrophic subaortic stenosis

MG Sutton, AJ Tajik, DG Gibson, DJ Brown, JB Seward and ER Guiliani

In order to study left ventricular function in idiopathic hypertrophic subaortic stenosis (IHSS), left ventricular echograms were analyzed by computer and compared with results in normal subjects. Systolic function was consistently normal or above normal even in the presence of severe diastolic abnormalities. Wide variation in diastolic function in IHSS allowed separation of patients into three groups on the basis of the left ventricular peak filling rate. Because of the severe septal hypertrophy and hypokinesia, peak left ventricular filling rate is predominantly determined by the rate of free wall thinning. Patients in group 1 had rapid left ventricular filling rates, those in group 2 had normal filling rates, and those in group 3 had slow filling rates. With reduction in left ventricular peak filling rate caused by impaired free wall thinning, there was progressive increase in 1) duration of the rapid filling phase, 2) delay of mitral valve opening, 3) asynchrony between septum and posterior wall, 4) incidence of angina, and 5) incidence of atrial fibrillation.

This article has been cited by other articles:

				J.-W. Ha, J.-R. Cho, J.-M. Kim, J.-A. Ahn, E.-Y. Choi, S.-M. Kang, S.-J. Rim, and N. Chung Tissue Doppler-Derived Indices Predict Exercise Capacity in Patients With Apical Hypertrophic Cardiomyopathy Chest, November 1, 2005; 128(5): 3428 - 3433. [Abstract] [Full Text] [PDF]

				S. Isobe, H. Izawa, Y. Takeichi, M. Nonokawa, M. Nanasato, A. Ando, K. Kato, M. Ikeda, T. Murohara, and M. Yokota Relationship Between Exercise-Induced Myocardial Ischemia and Reduced Left Ventricular Distensibility in Patients with Nonobstructive Hypertrophic Cardiomyopathy J. Nucl. Med., November 1, 2003; 44(11): 1717 - 1724. [Abstract] [Full Text] [PDF]

				Y Matsumura, P M Elliott, M S Virdee, P Sorajja, Y Doi, and W J McKenna Left ventricular diastolic function assessed using Doppler tissue imaging in patients with hypertrophic cardiomyopathy: relation to symptoms and exercise capacity Heart, March 1, 2002; 87(3): 247 - 251. [Abstract] [Full Text] [PDF]

				P. H. Pak, W. L. Maughan, K. L. Baughman, and D. A. Kass Marked Discordance Between Dynamic and Passive Diastolic Pressure-Volume Relations in Idiopathic Hypertrophic Cardiomyopathy Circulation, July 1, 1996; 94(1): 52 - 60. [Abstract] [Full Text]

				R. C. Harizi, J. A. Bianco, and J. S. Alpert Diastolic Function of the Heart in Clinical Cardiology Arch Intern Med, January 1, 1988; 148(1): 99 - 109. [Abstract] [PDF]