Circulation, Vol 57, 549-556, Copyright © 1978 by American Heart Association
FL Gobel, LA Norstrom, RR Nelson, CR Jorgensen and Y Wang
In order to evaluate hemodynamic predictors of myocardial oxygen
consumption (MVO2), 27 normotensive men with angina pectoris were studied
at rest and during a steady state at sympton-tolerated maximal exercise
(STME). Myocardial blood flow (MBF) was measured by the nitrous oxide
method using gas chromatography. MBF increased by 71% from a resting value
of 57.4 +/- 10.2 to 98.3 +/- 15.6 ml/100 g LV/min (P less than 0.001)
during STME while MVO2 increased by 81% from a resting value of 6.7 +/- 1.3
to 12.1 +/- 2.8 ml O2/100 g LV/min (P less than 0.001). MVO2 correlated
well with heart rate (HR) (r = 0.79), with HR x blood pressure (BP) (r =
0.83), and, adding end-diastolic pressure and peak LV dp/dt as independent
variables, slightly improved this correlation (r = .86). Including the
ejection period (tension-time index) did not improve the correlation (r =
0.80). Thus, HR and HR x BP, both easily measured hemodynamic variables,
are good predictors of MVO2 during exercise in normotensive patients with
ischemic heart disease. Including variables reflecting the contractile
state of the heart and ventricular volume may further improve the
predictability.
ARTICLES
The rate-pressure product as an index of myocardial oxygen consumption during exercise in patients with angina pectoris
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