Circulation, Vol 58, 425-433, Copyright © 1978 by American Heart Association
JS Gottdiener, HA Gross, WL Henry, JS Borer and MH Ebert
Cardiac size, function and rhythm were examined in 11 patients with
anorexia nervosa. Mean left ventricular, left atrial and aortic dimensions
on echocardiogram were below normal adult values at baseline. In addition
to decreased cardiac dimensions--ventricular ectopy, relative hypotension,
bradycardia and blunted heart rate-- response to exercise were noted. Left
ventricular systolic function, however, was unimpaired as indicated by
normal echocardiographic fractional shortening, and by normal exercise
augmentation of ejection fraction determined by radionuclide
cineangiography. Eight of the patients responded to treatment with a mean
weight gain of 32%. In these eight, cardiac dimensions increased toward
normal: left ventricular dimension increased by 13%; left atrial dimension
by 20%; aortic dimension by 15% and estimated left ventricular mass by 20%.
We conclude that abnormalities of heart size and rhythm occur in patients
with anorexia nervosa. However, cardiac dimensions, including left
ventricular mass, may increase following nutritional rehabilitation,
accompanied by an increase in heart rate and blood pressure.
ARTICLES
Effects of self-induced starvation on cardiac size and function in anorexia nervosa
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