Circulation, Vol 58, 739-746, Copyright © 1978 by American Heart Association
EA Fisher, FA Eckner, IW DuBrow and AR Hastreiter
To evaluate controlled pressure coronary artery perfusion fixation of
hearts as a means of obtaining meaningful cardiac measurements at autopsy,
left ventricular (LV) autopsy measurements were correlated with in vivo
end-diastolic (D) and end-systolic (S) angiographic (angio) values from
biplane cineangiograms in the same patients. Mitral (MV) and aortic valve
(AV) circumferences, LV equatorial circumference (Circ), spatial inflow and
outflow lengths, wall thickness (W) and LV volume (Vol) were measured in 34
children with congenital heart disease. All dimensions showed significant
correlation of angiographic and autopsy data from which linear regression
equations were derived. The r values obtained were: MV 0.74; AV 0.85; D
Circ 0.83; S Circ 0.82; D inflow 0.92; S inflow 0.90; D and S outflow 0.96;
W 0.78; D Vol 0.92; S Vol 0.86. Mean angio and autopsy values were not
significantly different for AV, S inflow, and S Vol. Autopsy values were
lower than all D angio values and MV (P less than 0.001 for all), and
higher than angio W and S outflow (P less than 0.001 for both). The data
show that changes of LV morphology with this fixation method are
predictable, making estimation of in vivo values from autopsy measurements
possible using the derived linear regression equations.
ARTICLES
Correlation of angiographic and autopsy left ventricular dimensions in children
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