Circulation, Vol 58, 908-915, Copyright © 1978 by American Heart Association
SH Zinner, HS Margolius, B Rosner and EH Kass
Previous studies in a population of 721 children aged 2--14 years
demonstrated the familial aggregation of blood pressure in children, and a
significant regression coefficient (b = 0.25) of follow-up on initial blood
pressures over a four-year period. Urinary kallikrein concentration (UKal)
also aggregated in families, was lower in black than in white children and
was inversely related to blood pressure. Further studies in the same cohort
have been conducted. These variables were again measured in 484 children in
129 families seven to eight years after the initial blood pressure and
three to four years after the original UKal measurements were made.
Familial aggregation again was found for blood pressure and urinary
kallikrein. Blood pressure tracking was demonstrated by the finding that
blood pressure scores at the third survey were related significantly to
those at both previous surveys. Kallikrein concentrations in casual urines
at Survey 3 were related to those obtained at Survey 2 (r = 0.499), and
were again significantly lower in black than in white children (log = 3.84
+/- 0.8 vs 4.37 +/- 0.7; P less than 0.001). These were significant inverse
relations between UKal/creatinine concentration and blood pressure in both
white and black children. Thus, familial aggregation of blood pressure,
blood pressure rank and concentration of kallikrein in casual urine
specimes are relatively stable in children over an eight-year period of
observation. This study demonstrates in a free living population of normal
children, a stable relation between blood pressure and an enzyme which is
involved in the production of potent vasodilator peptides and is related to
hypertension in adults.
ARTICLES
Stability of blood pressure rank and urinary kallikrein concentration in childhood: an eight-year follow-up
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