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Circulation, Vol 59, 1299-1304, Copyright © 1979 by American Heart Association

ARTICLES

Familial occurrence of mitral valve prolapse in X-linked muscular dystrophy

JH Biddison, DH Dembo, H Spalt, MG Hayes and CW LeDoux

A high incidence of mitral valve prolapse (MVP) has been reported in patients with X-linked Duchenne muscular dystrophy. In our study MVP was present in six of 22 Duchenne dystrophy cases (27%) followed in the Maryland General Hospital Muscular Dystrophy Clinic. In addition, seven carriers of Duchenne and X-linked benign (Becker) dystrophy had evidence of MVP. Autosomal dominant transmission of MVP was present in four families. The unusually high prevalence of MVP in families with X- linked muscular dystrophy may have potential value in the recognition of the carrier trait.

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