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(Circulation. 1952;6:276.)
© 1952 American Heart Association, Inc.

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The Inhibition of Coronary Atherosclerosis by Estrogens in Cholesterol-Fed Chicks

R. PICK M.D.¹; J. STAMLER M.D.¹; S. RODBARD M.D., Ph.D.¹; L. N. KATZ M.D.¹

¹ From the Cardiovascular Department, Medical Research Institute, Michael Reese Hospital.

Chronic administration of estrogens parenterally inhibits coronary atherogenesis in cockerels fed a cholesterol-supplemented diet, although no such prophylactic effect was observed against aorta atherogenesis. This protection of the coronary vessels is associated with depression of the plasma total cholesterol-lipid phosphorus ratio toward normal levels consequent upon estrogen-induced hyperphospholipemia.

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