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(Circulation. 1952;6:529.)
© 1952 American Heart Association, Inc.

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Aconitine-Induced Auricular Arrhythmias and Their Relation to Circus-Movement Flutter

BARBARA B. BROWN PH.D.¹ GEORGE H. ACHESON M.D.¹

¹ From the Pharmacology Department, Research Laboratories, The Wm. S. Merrell Company, Cincinnati 15, Ohio, and the Pharmacology Department, College of Medicine, University of Cincinnati, Cincinnati, Ohio.

Certain characteristics of aconitine-induced auricular arrhythmias in dogs and the responses of aconitine-induced flutter to various experimental procedures and to drugs are described. In certain experiments there was evidence that a secondary flutter mechanism had developed which, in some instances, resembled flutter of circus-movement origin. When aconitine-induced and circus-movement flutters were induced separately and simultaneously in auricles functionally divided by a crush, they responded to drugs in their characteristic manners. Aconitine-induced flutter slowed progressively and recovered gradually to flutter, whereas circus-movement flutter frequently reverted suddenly and permanently to sinus rhythm.

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