This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kerber, R. E. Articles by Marcus, M. L. Search for Related Content PubMed PubMed Citation Articles by Kerber, R. E. Articles by Marcus, M. L.

Circulation, Vol 60, 121-129, Copyright © 1979 by American Heart Association

ARTICLES

Effect of acute ischemia, nitroglycerin and nitroprusside on regional myocardial thickening, stress and perfusion. Experimental echocardiographic studies

RE Kerber, JB Martins and ML Marcus

The purposes of this study were to demonstrate that echocardiography can be used to demonstrate the systolic wall thinning of acutely ischemic myocardium, and to compare the effects of nitroglycerin and nitroprusside on systolic thinning, wall stress and perfusion of ischemic myocardium. In 37 dogs, the ratio of end-systolic-to-end- diastolic posterior wall thickness fell from 1.30 +/- 0.02 to 0.88 +/- 0.01 ((p less than 0.001) after circumflex coronary occlusion; perfusion of the area supplied by the occluded artery fell from 98.2 +/- 7.5 ml/100 g/min to 36.5 +/- 2.9 ml/100 g/min (p less than 0.001). Nitroglycerin and nitroprusside were given to lower mean arterial pressure by 7% and 15%. Despite the reduction in coronary perfusion pressure, transmural perfusion, endocardial/epicardial perfusion ratio and systolic thinning remained constant. Both drugs reduced the ischemic "wall stress index" (ventricular pressure x ventricular diameter/wall thickness) by almost 50%. Thus, both nitroglycerin and nitroprusside were equally beneficial in this model of acute myocardial ischemia.

This article has been cited by other articles:

				T. H. Marwick Safe Sex for Men With Coronary Artery Disease: Exercise, Sildenafil, and Risk of Cardiac Events JAMA, February 13, 2002; 287(6): 766 - 767. [Full Text] [PDF]

				V. Mor-Avi, K. A. Collins, C. E. Korcarz, M. Shah, K. T. Spencer, and R. M. Lang Detection of regional temporal abnormalities in left ventricular function during acute myocardial ischemia Am J Physiol Heart Circ Physiol, April 1, 2001; 280(4): H1770 - H1781. [Abstract] [Full Text] [PDF]

				N.G. Kounis, G.M. Zavras, P.J. Papadaki, G.D. Soufras, P.J. Vasilakos, E.A. Poulos, M.G. Papadimitriou, and G.V. Gouvelou-Deligianni Interventricular Septal Excursions and Velocities During Experimental Myocardial Ischemia. Effects of Nitroglycerin Infusion Vascular and Endovascular Surgery, May 1, 1991; 25(4): 259 - 266. [Abstract] [PDF]

				N.G. Kounis, G.M. Zavras, G.D. Soufras, P.J. Papadaki, E.A. Poulos, and D.J. Antoniou Left Ventricular Excursions and Velocities During Coronary Arterial Ligation. Effects of Nitroglycerin Infusion in an Experimental Model Angiology, October 1, 1989; 40(10): 899 - 906. [Abstract] [PDF]

				N. G. Kounis, G. M. Zavras, P. J. Papadaki, G. D. Soufras, and M. P. Kitrou Effects of Nitroglycerin on Myocardial Excursions and Velocities in the Early Hours of Acute Myocardial Infarction Angiology, September 1, 1989; 40(9): 783 - 790. [Abstract] [PDF]