This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Anderson, P. A. Articles by Floyd, R. D. Search for Related Content PubMed PubMed Citation Articles by Anderson, P. A. Articles by Floyd, R. D.

Circulation, Vol 60, 334-348, Copyright © 1979 by American Heart Association

ARTICLES

The force-interval relationship of the left ventricle

PA Anderson, A Manring, GA Serwer, DW Benson, SB Edwards, BE Armstrong, RJ Sterba and RD Floyd

We have carried out a quantitative analysis of the force-interval relationship of the human left ventricle and compared it to previous studies done in both intact subjects as well as isolated muscle. The characteristics of the force-interval relationship of the normal patient resembed those of normal isolated mammalian muscle (except when exposed to high levels of catecholamines). The relationship in group 2 (patients with increased left ventricular dimensions and normal pressure indices) resembled those obtained from isolated muscles from hypertrophied hearts. The relationship from group 3 (patients with increased left ventricular EDDs and depressed pressure indices, two of whom were in clinical heart failure) resumbled those induced in normal muscles exposed to high levels of catecholamines, and those obtained from experimentally induced heart failure. The force-interval relationships of the four patients who fell into the third group were strikingly different from the other groups. This suggests that the force-interval relationship may be useful to describe changes in the inotropic state of the patient's heart.

This article has been cited by other articles:

				K. E. Kjorstad, D. O. Nordhaug, C. Korvald, S. Muller, T. Steensrud, and T. Myrmel Mechanical restitution curves -- a possible load independent assessment of contractile function Eur. J. Cardiothorac. Surg., April 1, 2007; 31(4): 677 - 684. [Abstract] [Full Text] [PDF]

				Disruption of the ventricular myocardial force-frequency relationship after cardiac surgery in children: noninvasive assessment by means of tissue Doppler imaging. J. Thorac. Cardiovasc. Surg., March 1, 2006; 131(3): 625 - 631.

				R. W. Illes and K. D. Swoyer Prospective, Randomized Clinical Study of Ischemic Preconditioning as an Adjunct to Intermittent Cold Blood Cardioplegia Ann. Thorac. Surg., March 1, 1998; 65(3): 748 - 752. [Abstract] [Full Text] [PDF]

				S. F. Khoury, B. D. Hoit, V. Dave, C. M. Pawloski-Dahm, Y. Shao, M. Gabel, M. Periasamy, and R. A. Walsh Effects of Thyroid Hormone on Left Ventricular Performance and Regulation of Contractile and Ca2+-Cycling Proteins in the Baboon: Implications for the Force-Frequency and Relaxation-Frequency Relationships Circ. Res., October 1, 1996; 79(4): 727 - 735. [Abstract] [Full Text]

				S. D. Prabhu and G. L. Freeman Effect of Tachycardia Heart Failure on the Restitution of Left Ventricular Function in Closed-Chest Dogs Circulation, January 1, 1995; 91(1): 176 - 185. [Abstract] [Full Text]