Circulation, Vol 60, 473-485, Copyright © 1979 by American Heart Association
DB Zilversmit
The hypothesis that plasma chylomicrons in persons who ingest a
cholesterol-rich diet are atherogenic is evaluated. Evidence is presented
that in humans, and experimental animals, chylomicron remnants as well as
low-density lipoproteins are taken up by arterial cells. In persons who do
not have familial hyperlipoproteinemia, atherogenesis may occur during the
postprandial period. Research directions that may contribute to the
evaluation of chylomicron remnants as a risk factor for atherogenesis are
discussed. Lipoprotein studies after administration of a test meal
containing fat and cholesterol are urgently needed.
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Atherogenesis: a postprandial phenomenon
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