This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pang, L. M. Articles by Mellins, R. B. Search for Related Content PubMed PubMed Citation Articles by Pang, L. M. Articles by Mellins, R. B. Pubmed/NCBI databases Compound via MeSH Substance via MeSH

Circulation, Vol 60, 1503-1507, Copyright © 1979 by American Heart Association

ARTICLES

Increased circulating bradykinin during hypothermia and cardiopulmonary bypass in children

LM Pang, SA Stalcup, JS Lipset, CJ Hayes, FO Bowman Jr and RB Mellins

To determine whether cold could activate the kallikrein-kinin system in vivo as it does in vitro, the circulating systemic concentrations of bradykinin were serially measured in 10 cyildren with congenital diseases of the heart undergoing corrective cardiac surgery. Bradykinin was measured by radioimmunoassay in blood samples obtained before, during and after profound hypothermia (to 18 degrees C) and cardiopulmonary bypass. The circulating concentrations of bradykinin increased significantly as body temperature decreased during surface cooling. The increase in circulating bradykinin was associated with a decrease in the circulating level of bradykininogen, the precursor of bradykinin. With the onset of cardiopulmonary bypass and hence, removal of the lung and pulmonary converting enzyme from the circulation, there was a further rise in the already elevated concentrations of bradykinin. This is the first in vivo demonstration that hypothermia leads to an increase in the circulating concentrations of bradykinin.

This article has been cited by other articles:

				M. Cugno, J. Nussberger, P. Biglioli, F. Alamanni, R. Coppola, and A. Agostoni Increase of Bradykinin in Plasma of Patients Undergoing Cardiopulmonary Bypass : The Importance of Lung Exclusion Chest, December 1, 2001; 120(6): 1776 - 1782. [Abstract] [Full Text] [PDF]

				D. J. Campbell, B. Dixon, A. Kladis, M. Kemme, and J. D. Santamaria Activation of the kallikrein-kinin system by cardiopulmonary bypass in humans Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2001; 281(4): R1059 - R1070. [Abstract] [Full Text] [PDF]

				M. Nagashima, Y. Imai, K. Seo, M. Terada, M. Aoki, T. Shin'oka, and M. Koide Effect of hemofiltrated whole blood pump priming on hemodynamics and respiratory function after the arterial switch operation in neonates Ann. Thorac. Surg., December 1, 2000; 70(6): 1901 - 1906. [Abstract] [Full Text] [PDF]

				C. R. Smith and T. B. Spanier Aprotinin in deep hypothermic circulatory arrest Ann. Thorac. Surg., July 1, 1999; 68(1): 278 - 286. [Abstract] [Full Text] [PDF]

				M G Macey, D A McCarthy, U H Trivedi, G E Venn, D J Chambers, and K A Brown Neutrophil adhesion molecule expression during cardiopulmonary bypass: a comparative study of roller and centrifugal pumps Perfusion, September 1, 1997; 12(5): 293 - 301. [Abstract] [PDF]

				R. C. Gorman, N. P. Ziats, A. K. Rao, N. Gikakis, L. Sun, M. M. H. Khan, N. Stenach, S. Sapatnekar, V. Chouhan, J. H. Gorman III, et al. SURFACE-BOUND HEPARIN FAILS TO REDUCE THROMBIN FORMATION DURING CLINICAL CARDIOPULMONARY BYPASS J. Thorac. Cardiovasc. Surg., January 1, 1996; 111(1): 1 - 12. [Abstract] [Full Text]