Circulation, Vol 61, 808-814, Copyright © 1980 by American Heart Association
GC Davies, M Sobel and EW Salzman
Patients who underwent operations in which cardiopulmonary bypass was used
had elevations of plasma fibrinopeptide A which did not return to normal
during bypass despite conventional heparin anticoagulation, suggesting
inadequate heparin dosage and continued thrombin activity during the
operation. Patients who underwent aortocoronary artery grafting had high
plasma thromboxane B2 levels and a rapid fall in platelet count at the
onset of extracorporeal circulation. Thromboxane elevations were less
marked in patients who underwent valve replacement. Platelet aggregation
and coronary artery constriction secondary to thromboxane production may
contribute to the morbidity of cardiopulmonary bypass.
ARTICLES
Elevated plasma fibrinopeptide A and thromboxane B2 levels during cardiopulmonary bypass
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