This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Clarkson, P. M. Articles by Neutze, J. M. Search for Related Content PubMed PubMed Citation Articles by Clarkson, P. M. Articles by Neutze, J. M.

Circulation, Vol 62, 855-861, Copyright © 1980 by American Heart Association

ARTICLES

Developmental progress after cardiac surgery in infancy using hypothermia and circulatory arrest

PM Clarkson, BA MacArthur, BG Barratt-Boyes, RM Whitlock and JM Neutze

Seventy-two of 76 long-term survivors who had surgical repair of congenital heart lesions at 11 days to 26 months of age using profound hypothermia and circulatory arrest underwent psychometric testing (Stanford-Binet) late postoperatively. The mean IQ of the 72 patients was 92.9 +r16.5 (SD). Stanford-Binet scores bore no relationship to the duration of circulatory arrest or other aspects of surgical technique. Scores were significantly lower in those who had a low birth weight for gestational age, important neurologic problems preoperatively or were in the lower socioeconomic classes. An "ideal" control group of 69 children randomly selected from patients satisfying certain criteria based on birth and neonatal characteristics had a mean IQ of 106.2 +r11.6. Twenty-five patients who had surgical treatment of cogenital heart disease met the criteria for the control group except for their heart lesions. Their mean IQ was 101.4 +r15.0(NS). We could not demonstrate any significant deleterious effect that could be attributed to the surgical methods. Rather, the postoperative IQ scores reflected characteristics related to individual patients.

This article has been cited by other articles:

				P. A. Karsdorp, W. Everaerd, M. Kindt, and B. J.M. Mulder Psychological and Cognitive Functioning in Children and Adolescents with Congenital Heart Disease: A Meta-Analysis J. Pediatr. Psychol., June 1, 2007; 32(5): 527 - 541. [Abstract] [Full Text] [PDF]

				L. R. Blackmon, A. R. Stark, and and the Committee on Fetus and Newborn, American A Hypothermia: A Neuroprotective Therapy for Neonatal Hypoxic-Ischemic Encephalopathy Pediatrics, March 1, 2006; 117(3): 942 - 948. [Full Text] [PDF]

				R. M. Ungerleider and J. W. Gaynor The Boston Circulatory Arrest Study: An analysis J. Thorac. Cardiovasc. Surg., May 1, 2004; 127(5): 1256 - 1261. [Full Text] [PDF]

				T. R. Karl, S. Hall, G. Ford, E. A. Kelly, C. P. R. Brizard, R. B. B. Mee, R. G. Weintraub, A. D. Cochrane, and D. Glidden Arterial switch with full-flow cardiopulmonary bypass and limited circulatory arrest: Neurodevelopmental outcome J. Thorac. Cardiovasc. Surg., January 1, 2004; 127(1): 213 - 222. [Abstract] [Full Text]

				K. J. Griffin, T. D. Elkin, and C. J. Smith Academic Outcomes in Children with Congenital Heart Disease Clinical Pediatrics, June 1, 2003; 42(5): 401 - 409. [Abstract] [PDF]

				W. T. Mahle, R. R. Clancy, E. M. Moss, M. Gerdes, D. R. Jobes, and G. Wernovsky Neurodevelopmental Outcome and Lifestyle Assessment in School-Aged and Adolescent Children With Hypoplastic Left Heart Syndrome Pediatrics, May 1, 2000; 105(5): 1082 - 1089. [Abstract] [Full Text]

				F. A. Pigula, E. M. Nemoto, B. P. Griffith, and R. D. Siewers REGIONAL LOW-FLOW PERFUSION PROVIDES CEREBRAL CIRCULATORY SUPPORT DURING NEONATAL AORTIC ARCH RECONSTRUCTION J. Thorac. Cardiovasc. Surg., February 1, 2000; 119(2): 331 - 339. [Abstract] [Full Text] [PDF]

				D. C. Bellinger, D. Wypij, K. C. K. Kuban, L. A. Rappaport, P. R. Hickey, G. Wernovsky, R. A. Jonas, and J. W. Newburger Developmental and Neurological Status of Children at 4 Years of Age After Heart Surgery With Hypothermic Circulatory Arrest or Low-Flow Cardiopulmonary Bypass Circulation, August 3, 1999; 100(5): 526 - 532. [Abstract] [Full Text] [PDF]

				C. Limperopoulos, A. Majnemer, M. I. Shevell, B. Rosenblatt, C. Rohlicek, and C. Tchervenkov Neurologic Status of Newborns With Congenital Heart Defects Before Open Heart Surgery Pediatrics, February 1, 1999; 103(2): 402 - 408. [Abstract] [Full Text]

				L. A. Rappaport, D. Wypij, D. C. Bellinger, S. L. Helmers, G. L. Holmes, P. D. Barnes, G. Wernovsky, K. C. K. Kuban, R. A. Jonas, and J. W. Newburger Relation of Seizures After Cardiac Surgery in Early Infancy to Neurodevelopmental Outcome Circulation, March 3, 1998; 97(8): 773 - 779. [Abstract] [Full Text] [PDF]

				H. H. Hovels-Gurich, M.-C. Seghaye, S. Dabritz, B. J. Messmer, and G. von Bernuth COGNITIVE AND MOTOR DEVELOPMENT IN PRESCHOOL AND SCHOOL-AGED CHILDREN AFTER NEONATAL ARTERIAL SWITCH OPERATION J. Thorac. Cardiovasc. Surg., October 1, 1997; 114(4): 578 - 585. [Abstract] [Full Text]

				A. A. Bloom, J. A. Wright, R. D. Morris, R. M. Campbell, and N. S. Krawiecki Additive Impact of In-hospital Cardiac Arrest on the Functioning of Children With Heart Disease Pediatrics, March 1, 1997; 99(3): 390 - 398. [Abstract] [Full Text] [PDF]

				C. C. Eke, S. R. Gundry, M. F. Baum, R. E. Chinnock, A. J. Razzouk, and L. L. Bailey Neurologic Sequelae of Deep Hypothermic Circulatory Arrest in Cardiac Transplant Infants Ann. Thorac. Surg., March 1, 1996; 61(3): 783 - 787. [Abstract] [Full Text]

				G. Miller, J. R. Tesman, J. C. Ramer, B. G. Baylen, and J. L. Myers Outcome After Open-Heart Surgery in Infants and Children J Child Neurol, January 1, 1996; 11(1): 49 - 53. [Abstract] [PDF]

				R. K. Oates, J. M. Simpson, J. A. B. Turnbull, and T. B. Cartmill The relationship between intelligence and duration of circulatory arrest with deep hypothermia J. Thorac. Cardiovasc. Surg., September 1, 1995; 110(3): 786 - 792. [Abstract] [Full Text]

				G. Miller, K. D. Eggli, C. Contant, B. G. Baylen, and J. L. Myers Postoperative Neurologic Complications After Open Heart Surgery on Young Infants Arch Pediatr Adolesc Med, July 1, 1995; 149(7): 764 - 768. [Abstract] [PDF]

				D. C. Bellinger, R. A. Jonas, L. A. Rappaport, D. Wypij, G. Wernovsky, K. C.K. Kuban, P. D. Barnes, G. L. Holmes, P. R. Hickey, R. D. Strand, et al. Developmental and Neurologic Status of Children after Heart Surgery with Hypothermic Circulatory Arrest or Low-Flow Cardiopulmonary Bypass N. Engl. J. Med., March 2, 1995; 332(9): 549 - 555. [Abstract] [Full Text] [PDF]

				A. J. du Plessis, S. T. Treves, P. R. Hickey, L. O'Tuama, C. F. Barlow, J. Costello, A. R. Castaneda, and D. L. Wessel Regional cerebral perfusion abnormalities after cardiac operations: Single photon emission computed tomography (SPECT) findings in children with postoperative movement disorders J. Thorac. Cardiovasc. Surg., April 1, 1994; 107(4): 1036 - 1043. [Abstract] [Full Text]

				J. W. Newburger, R. A. Jonas, G. Wernovsky, D. Wypij, P. R. Hickey, K. Kuban, D. M. Farrell, G. L. Holmes, S. L. Helmers, J. Constantinou, et al. A Comparison of the Perioperative Neurologic Effects of Hypothermic Circulatory Arrest versus Low-Flow Cardiopulmonary Bypass in Infant Heart Surgery N. Engl. J. Med., October 7, 1993; 329(15): 1057 - 1064. [Abstract] [Full Text]

				J. E. MAYER JR Development, Growth, and Cardiac Surgery Arch Pediatr Adolesc Med, January 1, 1991; 145(1): 33 - 34. [Abstract] [PDF]