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Circulation. 1980;62:1127-1130

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Circulation, Vol 62, 1127-1130, Copyright © 1980 by American Heart Association

ARTICLES

The angiographic effect of ergonovine and nifedipine in coronary artery spasm

S Rich, LE Ford and J Al-Sadir

In a patient with variant angina, we have shown that the calcium- channel blocker nifedipine inhibits both spontaneous and ergonivine- induced coronary artery spasm. It had no effect, however, on the dose- related diffuse vasoconstriction caused by ergonovine, suggesting two distinct responses of coronary arteries to ergonovine provocation. Nifedipine did not cause epicardial coronary artery dilatation, as did nitroglycerin, supporting the rationale of using both therapies together to treat coronary artery spasm.




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