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Circulation. 1980;62:1357-1364

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Circulation, Vol 62, 1357-1364, Copyright © 1980 by American Heart Association

ARTICLES

Effects of isoproterenol on abnormal intraventricular conduction

MS Halpern, PA Chiale, GJ Nau, J Przybylski, JO Lazzari, MV Elizari and MB Rosenbaum

An isoproterenol infusion (1.0-4.0 microgram/min) was administered to 15 patients with intermittent bundle branch block (BBB) and two patients with apparently fixed BBB. Three main effects were documented: (1) In all patients with phase 3, or tachycardia-dependent, BBB, isoproterenol caused a pronounced shortening of refractoriness in the affected fascicle. (2) In patients showing phase 4, or bradycardia- dependent, BBB, isoproterenol prolonged the phase 4 block range, probably because of enhanced diastolic depolarization. In one patient (four studies) in whom phase 4 block was not present, isoproterenol caused the appearance of a phase 4 block range. (3) In the two patients with fixed BBB, isoproterenol restored conduction, probably as a result of a hyperpolarizing effect. This study shows that isoproterenol tends to restore or improve conduction related to tachycardia-dependent block, but may impair conduction related to bradycardia-dependent block.


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P. A. Chiale, I. Ferrari, E. Mahler, M. A. Vallazza, M. V. Elizari, M. B. Rosenbaum, and M. J. Levin
Differential Profile and Biochemical Effects of Antiautonomic Membrane Receptor Antibodies in Ventricular Arrhythmias and Sinus Node Dysfunction
Circulation, April 3, 2001; 103(13): 1765 - 1771.
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