Circulation, Vol 63, 117-121, Copyright © 1981 by American Heart Association
P Rubin, TF Blaschke and C Guilleminault
The study was designed to investigate the possible role of endogenous
opioids in the fall in blood pressure (BP) seen during initial sleep. Seven
normal men, ages 20-30 years, were studied for three consecutive nights.
Each night, electroencephalogram, chin electromyogram, electrooculogram,
heart rate (all continuously), and blood pressure (every 15 minutes) were
recorded. Night 1 was used for orientation. On nights 2 and 3, subjects
received, in randomized order, an infusion of naloxone 0.2 mg/kg over 1
minute or volume-matched saline. Blood pressure data from the first 4 hours
of non-rapid eye movement sleep were combined. On the placebo night,
systolic BP fell from 114.6 +/- 6 mm Hg to 103.7 +/- 8 mm Hg (+/- SD) (p
< 0.05, Wilcoxon rank-sum test). On the naloxone night, systolic BP did
not change. Neither diastolic BP nor heart rate were influenced by
naloxone. these data suggest that endogenous opioids could be involved in
the fall in systolic BP seen during initial sleep.
ARTICLES
Effect of naloxone, a specific opioid inhibitor, on blood pressure fall during sleep
This article has been cited by other articles:
 |
|
 |
|
  A. Cagnacci, L. Rovati, A. Zanni, S. Malmusi, F. Facchinetti, and A. Volpe Physiological doses of estradiol decrease nocturnal blood pressure in normotensive postmenopausal women Am J Physiol Heart Circ Physiol, April 1, 1999; 276(4): H1355 - H1360. [Abstract] [Full Text] [PDF]
|
|