This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ehsani, A. A. Articles by Holloszy, J. O. Search for Related Content PubMed PubMed Citation Articles by Ehsani, A. A. Articles by Holloszy, J. O.

Circulation, Vol 64, 1116-1124, Copyright © 1981 by American Heart Association

ARTICLES

Effects of 12 months of intense exercise training on ischemic ST- segment depression in patients with coronary artery disease

AA Ehsani, GW Heath, JM Hagberg, BE Sobel and JO Holloszy

This study was undertaken to determine whether adaptation to 12 months of intense endurance exercise training could alter the relationship between the product of heart rate and systolic blood pressure (double product) and the extent of ischemic ST-segment depression during exercise in patients with coronary artery disease. True (i.e., not symptom-limited) maximum oxygen uptake capacity increased from 25.5 +/- 4.2 ml/kg/min (mean +/- SD) to 35.3 +/- 4.4 ml/Kg/min with training. The maximum degree of ST-segment depression during exercise averaged 0.20 +/- 0.04 mV before and 0.16 +/- 0.08 mV after training despite a 20% increase in maximum double product. The double product at which ST depression (0.1 mV) first appeared was 22% greater after training. The extent of ST-segment displacement at the same double product was less after training. These findings suggest that training, if sufficiently intense and prolonged, can result in a reduction in myocardial ischemia at the same or a higher double product.

This article has been cited by other articles:

				C. Fiorina, E. Vizzardi, R. Lorusso, M. Maggio, G. De Cicco, S. Nodari, P. Faggiano, and L. Dei Cas The 6-min walking test early after cardiac surgery. Reference values and the effects of rehabilitation programme Eur. J. Cardiothorac. Surg., November 1, 2007; 32(5): 724 - 729. [Abstract] [Full Text] [PDF]

				M. Noel, J. Jobin, A. Marcoux, P. Poirier, G. R. Dagenais, and P. Bogaty Can prolonged exercise-induced myocardial ischaemia be innocuous? Eur. Heart J., July 1, 2007; 28(13): 1559 - 1565. [Abstract] [Full Text] [PDF]

				A. Arya, M. Maleki, F. Noohi, E. Kassaian, and F. Roshanali Myocardial Oxygen Consumption Index in Patients with Coronary Artery Disease Asian Cardiovasc Thorac Ann, March 1, 2005; 13(1): 34 - 37. [Abstract] [Full Text] [PDF]

				M Fujita and K Tambara Recent insights into human coronary collateral development Heart, March 1, 2004; 90(3): 246 - 250. [Abstract] [Full Text] [PDF]

				J. K. Williams, J. R. Kaplan, I. H. Suparto, J. L. Fox, and S. B. Manuck Effects of Exercise on Cardiovascular Outcomes in Monkeys With Risk Factors for Coronary Heart Disease Arterioscler. Thromb. Vasc. Biol., May 1, 2003; 23(5): 864 - 871. [Abstract] [Full Text] [PDF]

				P. Bogaty, P. Poirier, L. Boyer, J. Jobin, and G. R. Dagenais What Induces the Warm-Up Ischemia/Angina Phenomenon: Exercise or Myocardial Ischemia? Circulation, April 15, 2003; 107(14): 1858 - 1863. [Abstract] [Full Text] [PDF]

				H. S. Randeva, K. C. Lewandowski, J. Drzewoski, K. Brooke-Wavell, C. O'Callaghan, L. Czupryniak, E. W. Hillhouse, and G. M. Prelevic Exercise Decreases Plasma Total Homocysteine in Overweight Young Women with Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., October 1, 2002; 87(10): 4496 - 4501. [Abstract] [Full Text] [PDF]

				X.-Q. Zhang, L.-Q. Zhang, B. M. Palmer, Y.-C. Ng, T. I. Musch, R. L. Moore, and J. Y. Cheung Sprint training shortens prolonged action potential duration in postinfarction rat myocyte: mechanisms J Appl Physiol, May 1, 2001; 90(5): 1720 - 1728. [Abstract] [Full Text] [PDF]

				D J Wright, K M Khan, E M Gossage, and S Saltissi Assessment of a low-intensity cardiac rehabilitation programme using the six-minute walk test Clinical Rehabilitation, February 1, 2001; 15(2): 119 - 124. [Abstract] [PDF]

				S. Gielen, G. Schuler, and R. Hambrecht Exercise Training in Coronary Artery Disease and Coronary Vasomotion Circulation, January 2, 2001; 103 (1): e1 - e6. [Abstract] [Full Text] [PDF]

				L.-Q. Zhang, X.-Q. Zhang, T. I. Musch, R. L. Moore, and J. Y. Cheung Sprint training restores normal contractility in postinfarction rat myocytes J Appl Physiol, September 1, 2000; 89(3): 1099 - 1105. [Abstract] [Full Text] [PDF]

				L.-Q. Zhang, X.-Q. Zhang, Y.-C. Ng, L. I. Rothblum, T. I. Musch, R. L. Moore, and J. Y. Cheung Sprint training normalizes Ca2+ transients and SR function in postinfarction rat myocytes J Appl Physiol, July 1, 2000; 89(1): 38 - 46. [Abstract] [Full Text] [PDF]

				R. Hambrecht, A. Wolf, S. Gielen, A. Linke, J. Hofer, S. Erbs, N. Schoene, and G. Schuler Effect of Exercise on Coronary Endothelial Function in Patients with Coronary Artery Disease N. Engl. J. Med., February 17, 2000; 342(7): 454 - 460. [Abstract] [Full Text] [PDF]

				M. Fujita Heparin and angiogenic therapy Eur. Heart J., February 2, 2000; 21(4): 270 - 274. [PDF]

				L D Dugmore, R J Tipson, M H Phillips, E J Flint, N H Stentiford, M F Bone, and W A Littler Changes in cardiorespiratory fitness, psychological wellbeing, quality of life, and vocational status following a 12 month cardiac exercise rehabilitation programme Heart, April 1, 1999; 81(4): 359 - 366. [Abstract] [Full Text]