Circulation, Vol 64, 1142-1150, Copyright © 1981 by American Heart Association
FR Badke, RA Walsh, MH Crawford, T Ludden and RA O'Rourke
We examined the hemodynamic actions of clinically relevant i.v. doses (20
mg/kg and 10 mg/kg) of n-acetyl procainamide (NAPA) in conscious dogs
preinstrumented with a left ventricular (LV) micromanometer, LV and aortic
catheters, and ultrasonic crystals for measurement of LV internal diameter
shortening (% delta D). Within 30 seconds after the 20-mg/kg dose, there
were significant increases in heart rate (27 +/- 7 beats/min, mean +/- SEM;
n = 6), maximum dP/dt (655 +/- 206 mm Hg/sec), and % delta D (2.2 +/- 0.9%;
all p less than or equal to 0.05). However, by 6 hours after the dose there
were reductions compared with control in peak LV pressure (19 +/- 9 mm Hg),
dP/dt (610 +/- 210 mm Hg/sec), and % delta D (2.3 +/- 0.6%; all p less than
or equal to 0.05). In contrast, equimolar doses of procainamide or drug
vehicle alone evoked no response, as did NAPA after pretreatment with
reserpine (0.25 mg/kg/day for 2 days) or hexamethonium (10-15 mg/kg). These
data suggest NAPA produces a biphasic hemodynamic response with enhancement
of LV performance early and a decrease later; this response is different
from that of the parent compound, procainamide. These effects are likely
mediated by the adrenergic nervous system at either a ganglionic or a
central level.
ARTICLES
Hemodynamic effects of n-acetylprocainamide compared with procainamide in conscious dogs
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