Circulation, Vol 64, 1174-1184, Copyright © 1981 by American Heart Association
R Tatami, H Mabuchi, K Ueda, R Ueda, T Haba, T Kametani, S Ito, J Koizumi, M Ohta, S Miyamoto, A Nakayama, H Kanaya, H Oiwake, A Genda and R Takeda
The relationship between the concentrations of intermediate-density
lipoprotein (IDL) and other lipoproteins and the extent of coronary artery
disease (CAD) was studied in 182 consecutive patients evaluated by
selective coronary cineangiography. On univariate analysis, the extent of
CAD correlated significantly and positively with very low density
lipoprotein (VLDL) cholesterol, IDL cholesterol and low-density lipoprotein
(LDL) cholesterol, and negatively with high-density lipoprotein (HDL)
cholesterol. Analysis of four subgroups divided by IDL cholesterol and LDL
cholesterol levels indicated that moderately increased levels of IDL
cholesterol were closely associated with a high frequency of CAD. Moreover,
multi-variate regression analysis demonstrated that IDL cholesterol for
men, LDL cholesterol for men and women and HDL cholesterol for men were
significant variables of use in the final weighting procedure. IDL
cholesterol was closely associated with cholesterol-rich VLDL. This study
shows that IDL and cholesterol- rich VLDL combine to contribute to the
development of CAD.
ARTICLES
Intermediate-density lipoprotein and cholesterol-rich very low density lipoprotein in angiographically determined coronary artery disease
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