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Circulation, Vol 65, 281-285, Copyright © 1982 by American Heart Association

ARTICLES

Exacerbation of vasotonic angina pectoris by propranolol

RM Robertson, AJ Wood, WK Vaughn and D Robertson

Using a double-blind protocol, we investigated the use of propranolol in patients with coronary artery spasm as assessed by subjective and objective variables. Both low-dose (40 mg every 6 hours) and high-dose (160 mg every 6 hours) propranolol were administered. At both doses, the duration of angina attacks was significantly prolonged but the frequency was not. We conclude that propranolol at doses up to 160 mg every 6 hours as single therapy is frequently detrimental in angina pectoris due to coronary artery spasm and should not be used as the sole treatment of this disorder.

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