The potentiation of warfarin anticoagulation by amiodarone

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Circulation. 1982;65:1025-1029

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The potentiation of warfarin anticoagulation by amiodarone

A Hamer, T Peter, WJ Mandel, MM Scheinman and D Weiss

The potentiation of the anticoagulant effect of sodium warfarin by amiodarone is reported in 10 patients. Amiodarone appears to augment the depression of vitamin K-dependent coagulation factors caused by warfarin by an uncertain mechanism, and may lead to serious bleeding. The maintenance dose of warfarin should be halved when amiodarone and warfarin are prescribed together.

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				C. A. Sanoski and J. L. Bauman Clinical Observations With the Amiodarone/Warfarin Interaction : Dosing Relationships With Long-term Therapy Chest, January 1, 2002; 121(1): 19 - 23. [Abstract] [Full Text] [PDF]

				M. Naganuma, T. Shiga, K. Nishikata, T. Tsuchiya, H. Kasanuki, and E. Fujii Role of Desethylamiodarone in the Anticoagulant Effect of Concurrent Amiodarone and Warfarin Therapy Journal of Cardiovascular Pharmacology and Therapeutics, December 1, 2001; 6(4): 363 - 367. [Abstract] [PDF]

				B Cheung, F M Lam, and C R Kumana Lesson of the Week: Insidiously evolving, occult drug interaction involving warfarin and amiodarone BMJ, January 13, 1996; 312(7023): 107 - 108. [Full Text]

				N. Z. Kerin, R. D. Blevins, L. Goldman, K. Faitel, and M. Rubenfire The Incidence, Magnitude, and Time Course of the Amiodarone-Warfarin Interaction Arch Intern Med, August 1, 1988; 148(8): 1779 - 1781. [Abstract] [PDF]