Circulation, Vol 65, 1230-1235, Copyright © 1982 by American Heart Association
A Matsumori and C Kawai
Severe myocarditis was induced in inbred BALB/c mice inoculated with the M
variant of encephalomyocarditis (EMC) virus. The mortality rate was maximal
on the fourth day, then decreased gradually, but increased again between
the eleventh and fourteenth days. Gross myocardial lesions were seen on the
surface of the ventricles in 62 of 125 mice (49.6%) after the fifth day.
These myocardial lesions were observed more frequently in the dead mice (46
of 49, 93.9%). Cavity dimensions and wall thickness were measured in two
groups of mice with myocarditis. On days 5-7, the cavity dimensions of the
right (RV) and left (LV) ventricles in inoculated mice (0.92 +/- 0.51 mm
and 1.21 +/- 0.18 mm, respectively) were significantly larger than those in
controls (RV 0.54 +/- 0.17, LV 1.01 +/- 0.15; p less than 0.05). The wall
thickness of the RV (0.46 +/- 0.09, controls 0.64 +/- 0.11; p less than
0.001) and the LV (0.97 +/- 0.13, controls 1.12 +/- 0.19; p less than 0.05)
was significantly decreased. On days 8-14, dilatation of the LV was more
pronounced (1.48 +/- 0.37, p less than 0.005) than during days 5-7, and the
interventricular septum was also thinner. Pleural effusion, ascites and
congestion of the lungs and liver were noted, and death seemed due to
congestive heart failure. This study is the first documentation of
congestive heart failure after viral infection is an experimental animal.
ARTICLES
An experimental model for congestive heart failure after encephalomyocarditis virus myocarditis in mice
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