Circulation, Vol 65, 1365-1368, Copyright © 1982 by American Heart Association
GR Dreslinski, FH Messerli, FG Dunn, DH Suarez, E Reisin and ED Frohlich
Hemodynamic (systemic and regional), metabolic and cardiovascular reflexive
variables were measured before and after 4 weeks of beta blockade with
atenolol in 10 patients with mild essential hypertension. Atenolol reduced
mean arterial pressure, heart rate, cardiac index (all p less than 0.005)
and renal vascular resistance (p less than 0.01) and increased total
peripheral resistance (p less than 0.005). Glomerular filtration rate and
renal blood flow were unchanged; plasma renin activity fell 43%. Reflexive
cardioacceleration during the Valsalva maneuver and upright passive tilt
was blunted. No changes were observed in circulating fluid volumes. In six
patients followed for 1 year, blood pressure and heart rate were maintained
at levels similar to those during the first 4 weeks. Atenolol was shown to
be an effective oral antihypertensive that has no apparent deleterious
hemodynamic effects on the renal and splanchnic circulations.
ARTICLES
Hemodynamics, biochemical and reflexive changes produced by atenolol in hypertension
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