Circulation, Vol 65, 67-71, Copyright © 1982 by American Heart Association
This progress report on the prospective randomized study of the effect of
coronary bypass surgery on prognosis presents the results of a minimum
follow-up of 4 years. Seven hundred sixty-eight patients were recruited;
all were men younger than age 65 years who had mild-to- moderate angina
pectoris, at least two-vessel disease, and good left ventricular function.
Of these, 373 were randomized to medical treatment and 395 to surgical
treatment. Although 83 "medical" patients subsequently underwent surgery
and 27 "surgical" patients did not undergo surgery, these patients were not
excluded from the analysis, and the group randomized to coronary bypass
surgery was compared with the group randomized to medical treatment. The
surgical treatment group showed significantly better survival than the
medical treatment group in the total patient population (p less than
0.001), particularly among patients with three-vessel disease (p less than
0.001). Although the 24% higher survival among surgical patients with left
main coronary artery disease failed to reach statistical significance, the
trend is probably meaningful. No significant difference in survival between
medical and surgical treatment groups was noted in patients with two-
vessel disease.
ARTICLES
Prospective randomized study of coronary artery bypass surgery in stable angina pectoris: a progress report on survival
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