This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rozanski, A. Articles by Swan, H. J. Search for Related Content PubMed PubMed Citation Articles by Rozanski, A. Articles by Swan, H. J.

Circulation, Vol 67, 529-535, Copyright © 1983 by American Heart Association

ARTICLES

Improvement of resting myocardial asynergy with cessation of upright bicycle exercise

A Rozanski, U Elkayam, DS Berman, GA Diamond, J Prause and HJ Swan

Exercise generally aggravates ischemic myocardial dysfunction, presumably by increasing tissue oxygen demand out of proportion to the increase in supply. Nevertheless, resting left ventricular (LV) wall motion abnormalities can improve dramatically after upright exercise. To investigate this "paradoxical" phenomenon, we performed upright bicycle exercise equilibrium radionuclide ventriculography in 93 patients with angiographic coronary artery disease. Immediately after exercise, LV end-diastolic volume was similar to the resting level (1 +/- 22% of rest value), but end-systolic volume (ESV) was significantly below (p less than 0.05) that at rest (-11 +/- 32%) and LV ejection fraction increased significantly compared with rest (0.57 +/- 0.16 vs 0.51 +/- 0.13, p less than 0.05). Improvement in resting myocardial asynergy was frequent (115 of 330 abnormal segments), and was observed more commonly in patients without pathologic Q waves and in segments manifesting mild rather than severe asynergy. In 60 additional patients with resting asynergy who were also studied after nitroglycerin (NTG), there was 89% concordance of wall motion response in asynergic segments after exercise and NTG: 71 of 85 segments manifesting improvement with NTG also improved after exercise, and 157 of 172 segments without improvement with NTG also failed to improve after exercise. Despite the similar wall motion response, the mechanism of improvement is probably different from that produced by NTG. With NTG, preload (end-diastolic volume) and afterload (systolic blood pressure) were significantly lower than their resting control levels (p less than 0.05). These changes did not occur after exercise. Instead, an isolated, significant reduction in ESV was noted. These data support the hypothesis that catecholamine stimulation is responsible for paradoxical wall motion improvement after upright exercise.

This article has been cited by other articles:

				S. Borges-Neto, A. Javaid, L. K. Shaw, D. F. Kong, M. W. Hanson, R. A. Pagnanelli, G. Ravizzini, and R. E. Coleman Poststress Measurements of Left Ventricular Function with Gated Perfusion SPECT: Comparison with Resting Measurements by Using a Same-Day Perfusion-Function Protocol Radiology, May 1, 2000; 215(2): 529 - 533. [Abstract] [Full Text]

				S. A. McHam, T. H. Marwick, F. J. Pashkow, and M. S. Lauer Delayed systolic blood pressure recovery after graded exercise: An independent correlate of angiographic coronary disease J. Am. Coll. Cardiol., September 1, 1999; 34(3): 754 - 759. [Abstract] [Full Text] [PDF]

				L. Pavia, J. Myers, and R. Cesare Recovery Kinetics of Oxygen Uptake and Heart Rate in Patients With Coronary Artery Disease and Heart Failure Chest, September 1, 1999; 116(3): 808 - 813. [Abstract] [Full Text] [PDF]