Circulation, Vol 67, 968-977, Copyright © 1983 by American Heart Association
HB Hubert, M Feinleib, PM McNamara and WP Castelli
The relationship between the degree of obesity and the incidence of
cardiovascular disease (CVD) was reexamined in the 5209 men and women of
the original Framingham cohort. Recent observations of disease occurrence
over 26 years indicate that obesity, measured by Metropolitan Relative
Weight, was a significant independent predictor of CVD, particularly among
women. Multiple logistic regression analyses showed that Metropolitan
Relative Weight, or percentage of desirable weight, on initial examination
predicted 26-year incidence of coronary disease (both angina and coronary
disease other than angina), coronary death and congestive heart failure in
men independent of age, cholesterol, systolic blood pressure, cigarettes,
left ventricular hypertrophy and glucose intolerance. Relative weight in
women was also positively and independently associated with coronary
disease, stroke, congestive failure, and coronary and CVD death. These data
further show that weight gain after the young adult years conveyed an
increased risk of CVD in both sexes that could not be attributed either to
the initial weight or the levels of the risk factors that may have resulted
from weight gain. Intervention in obesity, in addition to the well
established risk factors, appears to be an advisable goal in the primary
prevention of CVD.
ARTICLES
Obesity as an independent risk factor for cardiovascular disease: a 26- year follow-up of participants in the Framingham Heart Study
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