Circulation, Vol 68, 1254-1263, Copyright © 1983 by American Heart Association
JP DiMarco, TD Sellers, RM Berne, GA West and L Belardinelli
Adenosine was administered intravenously to 17 patients undergoing
intracardiac electrophysiologic studies. At a mean dose of 179 +/- 88
micrograms/kg (+/- SD), adenosine suppressed sinus node automaticity and
depressed atrioventricular (AV) nodal conduction. These effects were less
than 20 sec in duration and were not influenced by muscarinic blockade with
atropine (0.02 to 0.03 mg/kg). Adenosine at this dose had no effect on
antegrade conduction over accessory pathways in patients with
Wolff-Parkinson-White syndrome. No independent hemodynamic effects were
observed. In six patients, adenosine was administered intravenously during
stimulation-induced paroxysmal supraventricular tachycardia. In the five
patients in whom the reentry loop of their tachycardia included the AV
node, adenosine at a mean dose of 83 +/- 35 micrograms/kg (+/- SD)
terminated their tachycardia within 20 sec after peripheral intravenous
injection. The dose of adenosine required to terminate these tachycardias
did not produce manifest sinus node suppression, and sinus rhythm promptly
resumed in all patients. Adenosine did not terminate either
supraventricular tachycardia due to intra-atrial reentry or atrial flutter,
but did produce transient AV block during these arrhythmias. Our findings
demonstrate that the human sinus and AV nodes are sensitive to physiologic
doses of adenosine and that adenosine may be used safely and effectively to
terminate acute episodes of supraventricular tachycardia that involve the
AV node in the reentry pathway.
ARTICLES
Adenosine: electrophysiologic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia
This article has been cited by other articles:
 |
|
 |
|
  J. H. Levy, K. A. Tanaka, and J. M. Bailey Cardiac Surgical Pharmacology Card. Surg. Adult, January 1, 2008; 3(2008): 77 - 110. [Full Text]
|
|
|
|
 |
|
 S. J. Swoap, M. Rathvon, and M. Gutilla AMP does not induce torpor Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R468 - R473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. L. Collins and S. E. DiCarlo Acute exercise increases the ventricular arrhythmia threshold via the intrinsic adenosine receptor system in conscious hypertensive rats Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1020 - H1026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Marin and K. G. Franchini Reduced oxygen supply explains the negative force-frequency relation and the positive inotropic effect of adenosine in buffer-perfused hearts Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H131 - H136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Tune, M. W. Gorman, and E. O. Feigl Matching coronary blood flow to myocardial oxygen consumption J Appl Physiol, July 1, 2004; 97(1): 404 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Gu, T. Ruan, J.-L. Hong, N. Burki, and L.-Y. Lee Selected Contribution: Hypersensitivity of pulmonary C fibers induced by adenosine in anesthetized rats J Appl Physiol, September 1, 2003; 95(3): 1315 - 1324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kirchhof, L. Fabritz, L. Fortmuller, G. P. Matherne, A. Lankford, H. A. Baba, W. Schmitz, G. Breithardt, J. Neumann, and P. Boknik Altered sinus nodal and atrioventricular nodal function in freely moving mice overexpressing the A1 adenosine receptor Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H145 - H153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Bailey, K. A. Tanaka, and J. H. Levy Cardiac Surgical Pharmacology Card. Surg. Adult, January 1, 2003; 2(2003): 85 - 118. [Full Text]
|
|
|
|
|
|
L. Wu, L. Belardinelli, J. A. Zablocki, V. Palle, and J. C. Shryock A partial agonist of the A1-adenosine receptor selectively slows AV conduction in guinea pig hearts Am J Physiol Heart Circ Physiol, January 1, 2001; 280(1): H334 - H343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G A Ng, W Martin, and A C Rankin Imaging of adenosine bolus transit following intravenous administration: insights into antiarrhythmic efficacy Heart, August 1, 1999; 82(2): 163 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Carmeliet Cardiac Ionic Currents and Acute Ischemia: From Channels to Arrhythmias Physiol Rev, July 1, 1999; 79(3): 917 - 1017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Glatter, J. Cheng, P. Dorostkar, G. Modin, S. Talwar, M. Al-Nimri, R. J. Lee, L. A. Saxon, M. D. Lesh, and M. M. Scheinman Electrophysiologic Effects of Adenosine in Patients With Supraventricular Tachycardia Circulation, March 2, 1999; 99(8): 1034 - 1040. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kwong, J.-L. Hong, R. F. Morton, and L.-Y. Lee Role of pulmonary C fibers in adenosine-induced respiratory inhibition in anesthetized rats J Appl Physiol, February 1, 1998; 84(2): 417 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Hatzinikolaou, L-M Rodriguez, J L R M Smeets, C Timmermans, G Vrouchos, G Grecas, and H J J Wellens Isoprenaline and inducibility of atrioventricular nodal re-entrant tachycardia Heart, February 1, 1998; 79(2): 165 - 168. [Abstract] [Full Text]
|
|
|
|
|
|
P. Alboni, C. Menozzi, M. Brignole, N. Paparella, G. Gaggioli, G. Lolli, and R. Cappato Effects of Permanent Pacemaker and Oral Theophylline in Sick Sinus Syndrome : The THEOPACE Study: A Randomized Controlled Trial Circulation, July 1, 1997; 96(1): 260 - 266. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. Wang, J. C. Shryock, and L. Belardinelli Cellular Basis for the Negative Dromotropic Effect of Adenosine on Rabbit Single Atrioventricular Nodal Cells Circ. Res., April 1, 1996; 78(4): 697 - 706. [Abstract] [Full Text]
|
|