| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Circulation, Vol 69, 721-727, Copyright © 1984 by American Heart Association
MA Thornton, AR Gruentzig, J Hollman, SB King 3d and JS Douglas
To determine the influence of adjunctive treatment with coumadin or aspirin
on recurrence rate after percutaneous transluminal coronary angioplasty
(PTCA), 248 patients in whom PTCA was assessed to be a primary success were
randomized to either 325 mm aspirin daily or to coumadin treatment
sufficient to maintain a prothrombin time 2 to 2.5 times the control value.
The follow-up protocol included stress testing and coronary angiographic
examinations 3 to 6 months after PTCA. All patients were followed for at
least 9 months. Of the 122 patients randomized to coumadin 44 (36%) had
recurrent stenoses as opposed to 34/126 (27%) of patients on aspirin, a
difference that did not reach statistical significance at the .05 level.
However, patients with at least a 6 month history of angina demonstrated a
significantly different response to adjunctive treatment in that 19/43
(44%) of coumadin patients as compared with 10/48 (21%) of aspirin patients
had recurrent stenoses (p less than .05). Thus, coumadin was not shown to
be more effective than aspirin as adjunctive treatment after PTCA, while
aspirin was shown to be superior to coumadin in patients with a longer
history of angina.
ARTICLES
Coumadin and aspirin in prevention of recurrence after transluminal coronary angioplasty: a randomized study
This article has been cited by other articles:
 |
|
 |
|
  R. C. Becker, T. W. Meade, P. B. Berger, M. Ezekowitz, C. M. O'Connor, D. A. Vorchheimer, G. H. Guyatt, D. B. Mark, and R. A. Harrington The Primary and Secondary Prevention of Coronary Artery Disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) Chest, June 1, 2008; 133(6_suppl): 776S - 814S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Schwartz, N. A. Chronos, and R. Virmani Preclinical restenosis models and drug-eluting stents: Still important, still much to learn J. Am. Coll. Cardiol., October 6, 2004; 44(7): 1373 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Popma, P. Berger, E. M. Ohman, R. A. Harrington, C. Grines, and J. I. Weitz Antithrombotic Therapy During Percutaneous Coronary Intervention: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy Chest, September 1, 2004; 126(3_suppl): 576S - 599S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Fontana, C. Giagulli, L. Cominacini, A. F. Pasini, P. Minuz, A. Lechi, A. Sala, and C. Laudanna {beta}2 Integrin-Dependent Neutrophil Adhesion Induced by Minimally Modified Low-Density Lipoproteins Is Mainly Mediated by F2-Isoprostanes Circulation, November 5, 2002; 106(19): 2434 - 2441. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F. Le Blanche, M. Bonneau, M. Wassef, M.-T. Farres, L. Gabez, B. Aubert, M. Duriez, B. I. Levy, J.-M. Bigot, and F. Boudghene Histomorphometric Evaluation of 198Au Endovascular Brachytherapy in a Renal Artery Restenosis Model in Rabbits Am. J. Roentgenol., September 1, 2002; 179(3): 611 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Sopko Preventing Cardiac Events and Restenosis After Percutaneous Coronary Intervention JAMA, June 26, 2002; 287(24): 3259 - 3261. [Full Text] [PDF]
|
|
|
|
|
|
J. M. t. Berg, B. A. Hutten, J. C. Kelder, F. W. A. Verheugt, and H. W. T. Plokker Oral Anticoagulant Therapy During and After Coronary Angioplasty : The Intensity and Duration of Anticoagulation Are Essential to Reduce Thrombotic Complications Circulation, April 24, 2001; 103(16): 2042 - 2047. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.Y Salame, S Verheye, I.R Crocker, N.A.F Chronos, K.A Robinson, and S.B King III Intracoronary radiation therapy Eur. Heart J., April 2, 2001; 22(8): 629 - 647. [PDF]
|
|
|
|
|
|
L. Iuliano, D. Pratico, C. Greco, E. Mangieri, G. Scibilia, G. A. FitzGerald, and F. Violi Angioplasty increases coronary sinus F2-isoprostane formation: evidence for in vivo oxidative stress during PTCA J. Am. Coll. Cardiol., January 1, 2001; 37(1): 76 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Popma, E. M. Ohman, J. Weitz, A. M. Lincoff, R. A. Harrington, and P. Berger Antithrombotic Therapy in Patients Undergoing Percutaneous Coronary Intervention Chest, January 1, 2001; 119(1_suppl): 321S - 336S. [Full Text] [PDF]
|
|
|
|
|
|
J. M. t. Berg, J. C. Kelder, M. J. Suttorp, E. G. Mast, E. Bal, S. M. P. G. Ernst, F. W. A. Verheugt, and H. W. T. Plokker Effect of Coumarins Started Before Coronary Angioplasty on Acute Complications and Long-Term Follow-Up : A Randomized Trial Circulation, July 25, 2000; 102(4): 386 - 391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Ogawa, T. Hayashi, T. Nakabayashi, N. Otani, K. Ishikawa, and K. Kanamasa Prevention of Coronary Arterial Renarrowing by Continuous 3-Day Infusion of Tissue Plasminogen Activator After Successful Percutaneous Transluminal Coronary Angioplasty: A Randomized, Double-Blind, Placebo-Controlled Study Angiology, May 1, 2000; 51(5): 367 - 375. [Abstract] [PDF]
|
|
|
|
|
|
A. Betriu, M. Masotti, A. Serra, J. Alonso, F. Fernandez-Aviles, F. Gimeno, T. Colman, J. Zueco, J. L. Delcan, E. Garcia, et al. Randomized comparison of coronary stent implantation and balloon angioplasty in the treatment of de novo coronary artery lesions (START): A four-year follow-up J. Am. Coll. Cardiol., November 1, 1999; 34(5): 1498 - 1506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gallo, A. Padurean, T. Jayaraman, S. Marx, M. Roque, S. Adelman, J. Chesebro, J. Fallon, V. Fuster, A. Marks, et al. Inhibition of Intimal Thickening After Balloon Angioplasty in Porcine Coronary Arteries by Targeting Regulators of the Cell Cycle Circulation, April 27, 1999; 99(16): 2164 - 2170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Labinaz, K. Pels, C. Hoffert, S. Aggarwal, and E. R O'Brien Time course and importance of neoadventitial formation in arterial remodeling following balloon angioplasty of porcine coronary arteries Cardiovasc Res, January 1, 1999; 41(1): 255 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Lansky, G. S. Mintz, J. J. Popma, A. D. Pichard, K. M. Kent, L. F. Satler, D. S. Baim, R. E. Kuntz, C. Simonton, R. M. Bersin, et al. Remodeling after directional coronary atherectomy (with and without adjunct percutaneous transluminal coronary angioplasty): a serial angiographic and intravascular ultrasound analysis from the optimal atherectomy restenosis study J. Am. Coll. Cardiol., August 1, 1998; 32(2): 329 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Rubartelli, L. Niccoli, E. Verna, C. Giachero, M. Zimarino, A. Fontanelli, C. Vassanelli, L. Campolo, E. Martuscelli, G. Tommasini, et al. Stent implantation versus balloon angioplasty in chronic coronary occlusions: results from the GISSOC trial J. Am. Coll. Cardiol., July 1, 1998; 32(1): 90 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.M. ten Berg, H.W.M. Plokker, A. Kastrati, F.J. Neumann, and A. Schomig Effect of Warfarin on Rate of Restenosis After PTCA • Response Circulation, May 26, 1998; 97(20): 2097 - 2098. [Full Text]
|
|
|
|
 |
|
 G. Franco Gensini, A. Colella, and M. Comeglio State-of-the-Art Review: Antiplatelet Agents and Thrombin Inhibitors: Combined Modality Therapy Clinical and Applied Thrombosis/Hemostasis, April 1, 1997; 3(2): 82 - 85. [PDF]
|
|
|
|
 |
|
 F. Versaci, A. Gaspardone, F. Tomai, F. Crea, L. Chiariello, and P. A. Gioffre A Comparison of Coronary-Artery Stenting with Angioplasty for Isolated Stenosis of the Proximal Left Anterior Descending Coronary Artery N. Engl. J. Med., March 20, 1997; 336(12): 817 - 822. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Guzman, V. Labhasetwar, C. Song, Y. Jang, A. M. Lincoff, R. Levy, and E. J. Topol Local Intraluminal Infusion of Biodegradable Polymeric Nanoparticles: A Novel Approach for Prolonged Drug Delivery After Balloon Angioplasty Circulation, September 15, 1996; 94(6): 1441 - 1448. [Abstract] [Full Text]
|
|
|
|
|
|
G. S. Mintz, J. J. Popma, A. D. Pichard, K. M. Kent, L. F. Satler, S. Chiu Wong, M. K. Hong, J. A. Kovach, and M. B. Leon Arterial Remodeling After Coronary Angioplasty : A Serial Intravascular Ultrasound Study Circulation, July 1, 1996; 94(1): 35 - 43. [Abstract] [Full Text]
|
|
|
|
|
|
S. B. King III Angioplasty From Bench to Bedside to Bench Circulation, May 1, 1996; 93(9): 1621 - 1629. [Full Text]
|
|
|
|
 |
|
 L. A. Guzman, M. J. Mick, A. M. Arnold, F. Forudi, and P. L. Whitlow Role of Intimal Hyperplasia and Arterial Remodeling After Balloon Angioplasty : An Experimental Study in the Atherosclerotic Rabbit Model Arterioscler. Thromb. Vasc. Biol., March 1, 1996; 16(3): 479 - 487. [Abstract] [Full Text]
|
|
|
|
|
|
C. M. Speidel, P. R. Eisenberg, W. Ruf, T. S. Edgington, and D. R. Abendschein Tissue Factor Mediates Prolonged Procoagulant Activity on the Luminal Surface of Balloon-Injured Aortas in Rabbits Circulation, December 1, 1995; 92(11): 3323 - 3330. [Abstract] [Full Text]
|
|
|
|
|
|
E. Camenzind, P.-P. Kint, C. Di Mario, J. Ligthart, W. van der Giessen, E. Boersma, and P. W. Serruys Intracoronary Heparin Delivery in Humans : Acute Feasibility and Long-term Results Circulation, November 1, 1995; 92(9): 2463 - 2472. [Abstract] [Full Text]
|
|
|
|
|
|
C. Rogers and E. R. Edelman Endovascular Stent Design Dictates Experimental Restenosis and Thrombosis Circulation, June 15, 1995; 91(12): 2995 - 3001. [Abstract] [Full Text]
|
|
|
|
|
|
A. E. Rodriguez, O. Santaera, M. Larribau, M. Fernandez, R. Sarmiento, N. P. Balino, J. B. Newell, G. S. Roubin, and I. F. Palacios Coronary Stenting Decreases Restenosis in Lesions With Early Loss in Luminal Diameter 24 Hours After Successful PTCA Circulation, March 1, 1995; 91(5): 1397 - 1402. [Abstract] [Full Text]
|
|
|
|
|
|
G. L. Nunes, D. S. Sgoutas, R. A. Redden, S. R. Sigman, M. B. Gravanis, S. B. King III, and B. C. Berk Combination of Vitamins C and E Alters the Response to Coronary Balloon Injury in the Pig Arterioscler. Thromb. Vasc. Biol., January 1, 1995; 15(1): 156 - 165. [Abstract] [Full Text]
|
|
|
|
|
|
P. W. Serruys, P. de Jaegere, F. Kiemeneij, C. Macaya, W. Rutsch, G. Heyndrickx, H. Emanuelsson, J. Marco, V. Legrand, P. Materne, et al. A Comparison of Balloon-Expandable-Stent Implantation with Balloon Angioplasty in Patients with Coronary Artery Disease N. Engl. J. Med., August 25, 1994; 331(8): 489 - 495. [Abstract] [Full Text]
|
|
|
|
|
|
D. L. Fischman, M. B. Leon, D. S. Baim, R. A. Schatz, M. P. Savage, I. Penn, K. Detre, L. Veltri, D. Ricci, M. Nobuyoshi, et al. A Randomized Comparison of Coronary-Stent Placement and Balloon Angioplasty in the Treatment of Coronary Artery Disease N. Engl. J. Med., August 25, 1994; 331(8): 496 - 501. [Abstract] [Full Text]
|
|
|
|
|
|
C. Landau, R. A. Lange, and L. D. Hillis Percutaneous Transluminal Coronary Angioplasty N. Engl. J. Med., April 7, 1994; 330(14): 981 - 993. [Full Text]
|
|
|
|
 |
|
 Antiplatelet Trialists Collaborative overview of randomised trials of antiplatelet therapy Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients BMJ, January 8, 1994; 308(6921): 81 - 106. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. K. Birinyi and F. W. Logerfo Intimal Hyperplasia: Evolving Concepts of Pathophysiology and Therapy Perspectives in Vascular Surgery and Endovascular Therapy, January 1, 1989; 2(2): 97 - 111. [PDF]
|
|