This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mori, H. Articles by Nakamura, Y. Search for Related Content PubMed PubMed Citation Articles by Mori, H. Articles by Nakamura, Y.

Circulation, Vol 70, 742-747, Copyright © 1984 by American Heart Association

ARTICLES

Protection of hypoxic myocardium by intracoronary administration of verapamil in open-chest dogs

H Mori, M Nagata, T Miyazaki, K Sakurai, S Ogawa, S Hattori, M Takahashi and Y Nakamura

Hypoxic perfusion of the regional myocardium was performed in 34 open- chest dogs. In eight dogs in which the myocardium was perfused with original hypoxic Krebs-Henseleit (K-H) solution for 5 min (group I) there was a marked decrease in adenosine triphosphate content (2.03 +/- 0.44 mumol/g) and an increase in lactate content (8.65 +/- 2.26 mumol/g). In myocardium of nine dogs (group II) perfused with verapamil- containing (1.3 mg/dl) K-H solution and in that of nine dogs (group III) receiving Ca2+-free solution, the degrees of reduction in adenosine triphosphate (2.99 +/- 0.73 and 3.25 +/- 0.48 mumol/g, respectively) and of lactate accumulation (5.16 +/- 0.59 and 4.79 +/- 1.02 mumol/g, respectively) at 5 min were significantly less than in group I. Absence of statistically significant differences in hemodynamic parameters among these three groups indicates that the metabolic preservation in group II probably resulted from a direct effect of verapamil on the regional myocardium related to Ca2+ metabolism. However, metabolic data in four dogs of group I and four dogs of group III killed at 40 sec of perfusion, in conjunction with results of the analysis of regional contraction, revealed that the time courses of segmental shortening in the three groups did not account for the metabolic differences among them.

This article has been cited by other articles:

				E. Tanaka, N. Hattan, K. Ando, H. Ueno, Y. Sugio, M. U. Mohammed, S. A. Voltchikhina, and H. Mori Amelioration of microvascular myocardial ischemia by gene transfer of vascular endothelial growth factor in rabbits J. Thorac. Cardiovasc. Surg., October 1, 2000; 120(4): 720 - 728. [Abstract] [Full Text] [PDF]