This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gidding, S. S. Articles by Rosenthal, A. Search for Related Content PubMed PubMed Citation Articles by Gidding, S. S. Articles by Rosenthal, A.

Circulation, Vol 71, 495-499, Copyright © 1985 by American Heart Association

ARTICLES

Increased forearm vascular reactivity in patients with hypertension after repair of coarctation

SS Gidding, AP Rocchini, C Moorehead, MA Schork and A Rosenthal

To determine whether altered vascular reactivity could contribute to hypertension after repair of coarctation, the change in forearm and calf vascular resistances to small intra-arterial infusions of norepinephrine were measured in six patients who had undergone surgical correction of coarctation of the aorta but still had upper extremity hypertension and compared with similar measurements made in five normotensive patients with mild heart disease. Only the mean upper extremity pressure was significantly greater in the group that underwent repair of coarctation (102 +/- 11 vs 83 +/- 5 mm Hg, p less than .05, for mean arm pressures and 96 +/- 13 vs 83 +/- 7 mm Hg for mean leg pressures in patients who had coarctation vs normotensive patients, respectively). Forearm and calf blood flows were measured in the right arm and leg with a mercury-in-plastic strain-gauge plethysmograph. Forearm and calf vascular resistances were calculated by dividing mean arterial pressure of the appropriate extremity by the blood flow of that extremity. Norepinephrine was infused into the right brachial and femoral arteries of the patients at doses of 0.02, 0.05, 0.1, 0.2, 0.3, 0.5, and 0.7 microgram/min. Resting forearm and calf vascular resistances were similar in both groups of patients. The norepinephrine dose-response curves showed that control patients required more than three times the norepinephrine to produce the same percent increase in forearm vascular resistance (after 0.2 microgram/min forearm vascular resistance increased by 55% in the coarctation group, while the resistance in the control group increased by only 3%, p less than .05).(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				S. Brili, D. Tousoulis, C. Antoniades, C. Vasiliadou, M. Karali, N. Papageorgiou, N. Ioakeimidis, K. Marinou, E. Stefanadi, and C. Stefanadis Effects of Ramipril on Endothelial Function and the Expression of Proinflammatory Cytokines and Adhesion Molecules in Young Normotensive Subjects With Successfully Repaired Coarctation of Aorta A Randomized Cross-Over Study. J. Am. Coll. Cardiol., February 19, 2008; 51(7): 742 - 749. [Abstract] [Full Text] [PDF]

				A. J. Donato, L. A. Lesniewski, and M. D. Delp Ageing and exercise training alter adrenergic vasomotor responses of rat skeletal muscle arterioles J. Physiol., February 15, 2007; 579(1): 115 - 125. [Abstract] [Full Text] [PDF]

				R.-E. W. Kavey, V. Allada, S. R. Daniels, L. L. Hayman, B. W. McCrindle, J. W. Newburger, R. S. Parekh, and J. Steinberger Cardiovascular Risk Reduction in High-Risk Pediatric Patients: A Scientific Statement From the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: Endorsed by the American Academy of Pediatrics Circulation, December 12, 2006; 114(24): 2710 - 2738. [Abstract] [Full Text] [PDF]

				J. Aboulhosn and J. S. Child Left Ventricular Outflow Obstruction: Subaortic Stenosis, Bicuspid Aortic Valve, Supravalvar Aortic Stenosis, and Coarctation of the Aorta Circulation, November 28, 2006; 114(22): 2412 - 2422. [Full Text] [PDF]

				M. Vogt, A. Kuhn, D. Baumgartner, C. Baumgartner, R. Busch, M. Kostolny, and J. Hess Impaired Elastic Properties of the Ascending Aorta in Newborns Before and Early After Successful Coarctation Repair: Proof of a Systemic Vascular Disease of the Prestenotic Arteries? Circulation, June 21, 2005; 111(24): 3269 - 3273. [Abstract] [Full Text] [PDF]

				J. W.J. Vriend, A. H. Zwinderman, E. de Groot, J. J.P. Kastelein, B. J. Bouma, and B. J.M. Mulder Predictive value of mild, residual descending aortic narrowing for blood pressure and vascular damage in patients after repair of aortic coarctation Eur. Heart J., January 1, 2005; 26(1): 84 - 90. [Abstract] [Full Text] [PDF]

				P. Ou, D. Bonnet, L. Auriacombe, E. Pedroni, F. Balleux, D. Sidi, and E. Mousseaux Late systemic hypertension and aortic arch geometry after successful repair of coarctation of the aorta Eur. Heart J., October 2, 2004; 25(20): 1853 - 1859. [Abstract] [Full Text] [PDF]

				D S Celermajer and K Greaves Survivors of coarctation repair: fixed but not cured Heart, August 1, 2002; 88(2): 113 - 114. [Full Text] [PDF]

				M. de Divitiis, C. Pilla, M. Kattenhorn, M. Zadinello, A. Donald, P. Leeson, S. Wallace, A. Redington, and J. E. Deanfield Vascular dysfunction after repair of coarctation of the aorta: Impact of Early Surgery Circulation, September 18, 2001; 104(90001): I-165 - 170. [Abstract] [Full Text] [PDF]

				J. Gunthard, P. T. Buser, R. Miettunen, A. Hagmann, and F. Wyler Effects of Morphologic Restenosis, Defined by MRI After Coarctation Repair, on Blood Pressure and Arm-Leg and Doppler Gradients Angiology, November 1, 1996; 47(11): 1073 - 1080. [Abstract] [PDF]

				J. A. Pawelczyk and B. D. Levine Heterogeneous responses of human limbs to infused adrenergic agonists: a gravitational effect? J Appl Physiol, May 1, 2002; 92(5): 2105 - 2113. [Abstract] [Full Text] [PDF]