Circulation, Vol 71, 595-601, Copyright © 1985 by American Heart Association
DL Johnston, TJ Brady, AV Ratner, BR Rosen, JB Newell, GM Pohost and RD Okada
Proton (hydrogen-1) magnetic resonance imaging techniques have potential
for the detection and characterization of changes associated with
myocardial ischemia. Since image contrast is dependent on T1 and T2
relaxation times, we examined these parameters in a canine preparation of
occlusion of the left anterior descending coronary artery. Of 16 dogs
studied, seven underwent 3 hr of coronary artery occlusion and nine
underwent 3 hr of occlusion followed by 1 hr of reperfusion. After the dogs
were killed, the hearts of four from each group were imaged in a small
bore, 1.4 tesla magnet. From all hearts myocardial segments were obtained
from the normal zone and the central ischemic zone (CZ). These segments
were divided into epicardial and endocardial sections and studied in a
spectrometer (20 MHz). After 3 hr of occlusion, CZ endocardial T1 and T2
increased significantly (p less than .01 and p less than .05,
respectively). Changes in CZ epicardial relaxation times were not as
marked. Although T1 and T2 tended to be higher in the reperfused group
compared with the nonreperfused group, the differences did not reach
statistical significance. In keeping with the spectrometric findings,
T1-dependent inversion recovery images and T2-dependent spin-echo images of
the excised hearts demonstrated excellent contrast between normal and
ischemic myocardium. Modest correlations were noted for both groups between
blood flows during occlusion measured by the microsphere technique and T1
and T2 relaxation times. In summary, relaxation times T1 and T2 increase
regionally after 3 hr of coronary artery occlusion and tend to be
accentuated by reperfusion.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Assessment of myocardial ischemia with proton magnetic resonance: effects of a three hour coronary occlusion with and without reperfusion
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