Circulation, Vol 71, 1170-1178, Copyright © 1985 by American Heart Association
SR Cannon, KL Richards and M Crawford
To determine the source of errors in the Gorlin formula for estimating
stenotic valvular orifice area, we used a pulsatile flow model that
emulated left ventricular and aortic pressures and flow and allowed control
of ventricular outflow orifice area. After comparing orifice areas
calculated by the Gorlin formula with actual orifice areas, the Gorlin
formula constant (k) was found to be highly correlated with the square root
of the mean transvalvular gradient (r = .95). A new formula was derived
empirically and predicted areas more accurately and with smaller standard
errors than the Gorlin formula in the model (r = .98, SEE = 0.11 and r =
.87, SEE = 0.28, respectively) in a series of 19 patients with Hancock
porcine xenograft valves (r = .89, SEE = 0.07 and r = .60, SEE = 0.12,
respectively) and in the original series of patients reported by Gorlin and
Gorlin in proposing the Gorlin formula (r = .93, SEE = 0.11 and r = .91,
SEE = 0.12, respectively).
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Hydraulic estimation of stenotic orifice area: a correction of the Gorlin formula
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