Circulation, Vol 71, 1279-1291, Copyright © 1985 by American Heart Association
KP Gallagher, MC Stirling, M Choy, CA Szpunar, RA Gerren, MJ Botham and JH Lemmer
The relationship between epicardial and transmural function (measured with
sonomicrometers) was examined in 13 anesthetized open-chest dogs. Systolic
wall thickening was used as a standard of integrated transmural function to
compare with epicardial function measured as segment shortening parallel to
surface fibers. Three levels of coronary inflow restriction were produced
by using decrements in systolic wall thickening as an index of changes in
the transmural distribution of myocardial blood flow (microspheres) in
myocardium perfused by the left anterior descending artery (anterior-apical
group, n = 7) or circumflex artery (posterior-basal group, n = 6). Levels 1
and 2 were characterized by reductions in systolic wall thickening of 35%
and 80%, respectively, and marked decreases in deep myocardial blood flow.
In the subepicardium, myocardial blood flow was minimally affected at
levels 1 and 2 and there was no change in posterior-basal epicardial
segment shortening, but anterior segment shortening decreased significantly
(by 21% and 37%, respectively). At level 3 myocardial blood flow was
reduced transmurally, producing systolic wall thinning and marked
epicardial dysfunction in both groups. Parallel epicardial segment
shortening underestimated the extent of transmural dysfunction in both
groups at levels 1 and 2 but the degree of underestimation was greatest in
the posterior-basal group. Anterior-apical segment shortening was impaired
at levels 1 and 2, whereas posterior-basal segment shortening was
unaffected, suggesting that significant regional variability exists in the
epicardial response to nontransmural ischemia.
ARTICLES
Dissociation between epicardial and transmural function during acute myocardial ischemia
This article has been cited by other articles:
 |
|
 |
|
  B. Bijnens, P. Claus, F. Weidemann, J. Strotmann, and G. R. Sutherland Investigating Cardiac Function Using Motion and Deformation Analysis in the Setting of Coronary Artery Disease Circulation, November 20, 2007; 116(21): 2453 - 2464. [Full Text] [PDF]
|
|
|
|
 |
|
 O. A. Smiseth and H. Ihlen Strain rate imaging: why do we need it? J. Am. Coll. Cardiol., November 5, 2003; 42(9): 1584 - 1586. [Full Text] [PDF]
|
|
|
|
|
|
S. B. Yeon, N. Reichek, B. A. Tallant, J. A. C. Lima, L. P. Calhoun, N. R. Clark, E. A. Hoffman, K. K. L. Ho, and L. Axel Validation of in vivo myocardial strain measurement by magnetic resonance tagging with sonomicrometry J. Am. Coll. Cardiol., August 1, 2001; 38(2): 555 - 561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Derumeaux, J. Loufoua, G. Pontier, A. Cribier, and M. Ovize Tissue Doppler Imaging Differentiates Transmural From Nontransmural Acute Myocardial Infarction After Reperfusion Therapy Circulation, January 30, 2001; 103(4): 589 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Derumeaux, M. Ovize, J. Loufoua, G. Pontier, X. Andre-Fouet, and A. Cribier Assessment of Nonuniformity of Transmural Myocardial Velocities by Color-Coded Tissue Doppler Imaging : Characterization of Normal, Ischemic, and Stunned Myocardium Circulation, March 28, 2000; 101(12): 1390 - 1395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Colonna, R. Montisci, L. Galiuto, L. Meloni, and S. Iliceto Effects of acute ischaemia on intramyocardial contraction heterogeneity; new ultrasound technologies to study an old phenomenon Eur. Heart J., March 1, 1999; 20(5): 327 - 337. [PDF]
|
|
|
|
 |
|
 X. Bian, A. G. Williams Jr., P. A. Gwirtz, and H. F. Downey Right coronary autoregulation in conscious, chronically instrumented dogs Am J Physiol Heart Circ Physiol, July 1, 1998; 275(1): H169 - H175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Klein, S. Pich, R. M. Bohle, J. Wollenweber, and K. Nebendahl Myocardial Protection by Na+-H+ Exchange Inhibition in Ischemic, Reperfused Porcine Hearts Circulation, August 15, 1995; 92(4): 912 - 917. [Abstract] [Full Text]
|
|