Circulation, Vol 71, 1301-1308, Copyright © 1985 by American Heart Association
WC Little, GL Freeman and RA O'Rourke
The left ventricular end-systolic pressure-volume relationship is a
load-insensitive measure of left ventricular performance. The relationship
at end-systole between left ventricular pressure and dimension is more
easily obtained, but the conflicting results of previous studies make it
unclear if it has the same properties as the left ventricular end-systolic
pressure-volume relationship. To address this issue, 11 dogs were
instrumented to measure left ventricular pressure and three orthogonal left
ventricular dimensions. Left ventricular pressure and dimensions were
varied by use of caval occlusion. Left ventricular volume was calculated as
an ellipsoid. The left ventricular end-systolic pressure-volume
relationship and each of the three end-systolic pressure-dimension
relations were described by straight lines (r = .97 +/- .02, mean +/- SD).
In six animals, dobutamine produced similar significant increases (p less
than .01) in the slope of the end-systolic pressure-volume relationship
(244 +/- 61% of control), the end-systolic pressure-anterior-posterior
dimension relationship (248 +/- 89%), the end-systolic
pressure--septal-lateral dimension relationship (211 +/- 95%), and the
end-systolic pressure- basal-apical dimension relationship (210 +/- 85%).
The intercepts at zero pressure were relatively unchanged by dobutamine. In
contrast, occlusion of the distal left anterior descending coronary artery
in five animals produced a rightward shift of the left ventricular end-
systolic pressure-volume relationship and the pressure--basal-apical
dimension relationship, while the pressure--anterior-posterior dimension
and pressure--septal-lateral dimension relationships were relatively
unaffected.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Simultaneous determination of left ventricular end-systolic pressure- volume and pressure-dimension relationships in closed-chest dogs
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