Circulation, Vol 72, 585-595, Copyright © 1985 by American Heart Association
MJ Janse, PJ Schwartz, F Wilms-Schopman, RJ Peters and D Durrer
We recorded direct-current extracellular electrograms simultaneously from
60 left ventricular epicardial sites in 38 alpha-chloralose- anesthetized
dogs during repeated, 5 min coronary arterial occlusions. In each dog
recordings made during control occlusions were compared with those made in
occlusions after, or during, the following interventions on the sympathetic
nervous system: left stellate ganglion stimulation, left stellectomy, right
stellectomy, and clamping the abdominal aorta with intact sympathetic
nerves to induce a rise of blood pressure equal to that present during left
stellate stimulation. Heart rate was kept constant. Measurements included
determination of TQ segment potentials and times of local activation. After
2 min of ischemia, the degree of TQ segment depression was increased by
left stellate ganglion stimulation and was decreased by both left
stellectomy and clamping the aorta. Also, the area showing negative TQ
potentials, indicating decreased resting membrane potentials, was enlarged
by both left stellate stimulation and right stellectomy and reduced by left
stellectomy. No differences were found in the results of experiments in
which the left anterior descending coronary artery was occluded and those
in which the circumflex branch was occluded. Left stellate stimulation
significantly improved conduction within the ischemic zone. No evidence was
found to suggest that the arrhythmogenic effects of left stellate
stimulation and of right stellectomy, confirmed in the present study,
resulted from an increased likelihood for reentry in the subepicardium of
the ischemic zone.
ARTICLES
Effects of unilateral stellate ganglion stimulation and ablation on electrophysiologic changes induced by acute myocardial ischemia in dogs
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