Circulation, Vol 72, 654-659, Copyright © 1985 by American Heart Association
WL Maughan, K Sunagawa, D Burkhoff, WL Graves Jr, WC Hunter and K Sagawa
Although the rate dependence of isolated muscle contractility is well
known, the ventricular end-systolic pressure-volume relationship (ESPVR)
has been reported to be insensitive to heart rate. To resolve this
contradiction, we used an isolated, ejecting canine heart preparation
perfused at a constant coronary arterial pressure. Heart rate was changed
from 60 to 200 beats/min in steps of 20 beats/min. At least 10
pressure-volume loops under different filling pressures were obtained at
each heart rate in each of six hearts. Over a heart rate range from 60 to
120 beats/min, the slope of the ESPVR (Ees) increased significantly from
3.5 +/- 0.4 (SE) to 5.3 +/- 0.6 mm Hg/ml. In the range between 120 and 180
beats/min there was little change in Ees (5.3 +/- 0.6 to 5.4 +/- 0.6 mm
Hg/ml), but at 200 beats/min Ees increased slightly to 5.7 +/- 0.5 mm
Hg/ml. The volume axis intercept (V0) of the ESPVR changed little over the
range of heart rate from 60 to 160 beats/min (10.2 +/- 2 ml to 9.4 +/- 1.3
ml) but increased to 15.2 +/- 1.2 ml at a rate of 200 beats/min. The change
in ESPVR with increase in heart rate from 60 to 120 beats/min (i.e.,
increase in Ees without change in V0) is the same as those seen with a
positive inotropic intervention with calcium or cathecholamines, whereas
the V0 changes over the range from 160 to 200 beats/min is similar to those
seen with regional ischemia.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Effect of heart rate on the canine end-systolic pressure-volume relationship
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