Circulation, Vol 72, 915-921, Copyright © 1985 by American Heart Association
ML Myers, R Bolli, RF Lekich, CJ Hartley and R Roberts
Reperfusion after reversible regional ischemia has been shown to result in
delayed recovery of myocardial function, but the mechanism responsible for
this phenomenon remains unknown. We explored the potential role of
oxygen-free radicals as mediators of postischemic dysfunction in open-chest
dogs undergoing a 15 min occlusion of the left anterior descending coronary
artery (LAD) followed by 2 hr of reperfusion. Treated animals (n = 19)
received an infusion of the oxygen free-radical scavengers superoxide
dismutase (SOD; 15,000 U/kg) and catalase (CAT; 55,000 U/kg) for 1 hr
starting 15 min before LAD occlusion, while control animals (n = 20)
received an equal volume of saline. SOD and CAT produced no discernible
effect on heart rate, aortic pressure, or left atrial pressure. Collateral
flow to the ischemic zone (radioactive microspheres) was 0.07 +/- 0.01
ml/min/g in both groups. The size of the occluded bed as determined by
postmortem perfusion was 26.1 +/- 1.2% of the left ventricle in the control
group and 26.5 +/- 0.9% in the treated group. Systolic wall thickening (an
index of regional function) was assessed with an epicardial pulsed- Doppler
probe. The two groups exhibited comparable systolic thickening under
baseline conditions and similar degrees of dyskinesia during ischemia.
Nevertheless, recovery of function (expressed as percent of baseline) was
considerably greater in the treated dogs, both at 1 hr (43.8 +/- 14.3 vs
12.8 +/- 11.6) and 2 hr of reperfusion (74.2 +/- 8.4 vs 31.6 +/- 9.8, p
less than .005). This improved recovery of function obtained with SOD and
CAT suggests that oxygen-free radicals play an important role in the
genesis of myocardial dysfunction after a brief episode of regional
ischemia.
ARTICLES
Enhancement of recovery of myocardial function by oxygen free-radical scavengers after reversible regional ischemia
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