Circulation, Vol 72, 1372-1379, Copyright © 1985 by American Heart Association
CK Millar, FA Kralios and RL Lux
Unipolar electrograms from ventricular epicardium in dogs were analyzed for
the timing of local excitation and repolarization with computer assistance.
The most rapid decrease in voltage in the QRS (dV/dt min) was used to
determine local excitation time, and the maximum rate of voltage increase
(dV/dt max) near the peak of the T wave was used to time local
repolarization. The difference between dV/dt min and dV/dt max, the
activation-recovery interval, is theoretically related to the net effect of
the durations of the action potentials at that site. Paired data for
refractory periods and activation-recovery intervals obtained from the same
electrodes during fixed activation orders were obtained before and during
repolarization changes induced by changes in cycle length, infusion of
norepinephrine, and cardiac sympathetic nerve stimulation. Correlation
coefficients were close to 1.00 and standard errors were 2.0 to 4.3 msec
for changes at individual sites. Pooling of data from multiple sites
increased standard errors and reduced correlation coefficients. Results
provide quantification of errors in the use of unipolar electrograms to
time local repolarization changes induced by variations in rate and
adrenergic tone. They should increase the practical usefulness of the
unipolar electrogram as a tool for assessing the time course and spatial
distribution of repolarization changes.
ARTICLES
Correlation between refractory periods and activation-recovery intervals from electrograms: effects of rate and adrenergic interventions
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