Circulation, Vol 73, 572-578, Copyright © 1986 by American Heart Association
JH Ashton, CR Benedict, C Fitzgerald, S Raheja, A Taylor, WB Campbell, LM Buja and JT Willerson
The data obtained in this study demonstrate that the concentration of
serotonin is markedly elevated (18- to 27-fold) at the site of a coronary
arterial stenosis in open-chest, anesthetized dogs with cyclic flow
variations. Cyclic flow variations in this experimental preparation were
abolished by ketanserin, a 5-hydroxytryptamine antagonist, but serotonin
concentration at the site of the coronary stenosis remained elevated. The
intra-atrial administration of serotonin (0.16 to 1 mg/min) restored cyclic
flow variations after they had been abolished by ketanserin. Taken
together, these data suggest that serotonin may be one of the important
mediators of cyclic flow variations in this experimental preparation.
ARTICLES
Serotonin as a mediator of cyclic flow variations in stenosed canine coronary arteries
This article has been cited by other articles:
 |
|
 |
|
  J. W. Adams, J. Ramirez, Y. Shi, W. Thomsen, J. Frazer, M. Morgan, J. E. Edwards, W. Chen, B. R. Teegarden, Y. Xiong, et al. APD791, 3-Methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide, a Novel 5-Hydroxytryptamine 2A Receptor Antagonist: Pharmacological Profile, Pharmacokinetics, Platelet Activity and Vascular Biology J. Pharmacol. Exp. Ther., October 1, 2009; 331(1): 96 - 103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. R. Wulsin, D. Musselman, C. Otte, E. Bruce, S. Ali, and M. A. Whooley Depression and Whole Blood Serotonin in Patients With Coronary Heart Disease From the Heart and Soul Study Psychosom Med, April 1, 2009; 71(3): 260 - 265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Watanabe, K. Nishio, T. Kanome, T.-a. Matsuyama, S. Koba, T. Sakai, K. Sato, S. Hongo, K. Nose, H. Ota, et al. Impact of Salusin-{alpha} and -{beta} on Human Macrophage Foam Cell Formation and Coronary Atherosclerosis Circulation, February 5, 2008; 117(5): 638 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-S. Wong, A. Asmat, Y.-H. Chan, and C.-N. Lee A randomized, double-blind, placebo-controlled trial of a COX-2 inhibitor (Rofecoxib) in patients undergoing coronary artery bypass surgery Interactive CardioVascular and Thoracic Surgery, April 1, 2006; 5(2): 101 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S U Shah, A White, S White, and W A Littler Heart and mind: (1) relationship between cardiovascular and psychiatric conditions Postgrad. Med. J., December 1, 2004; 80(950): 683 - 689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Serebruany, A. H. Glassman, A. I. Malinin, C. B. Nemeroff, D. L. Musselman, L. T. van Zyl, M. S. Finkel, K. R. R. Krishnan, M. Gaffney, W. Harrison, et al. Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events: The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy Circulation, August 26, 2003; 108(8): 939 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Cao, J. H. Han, S. Z. Kim, K. W. Cho, and S. H. Kim Diverse regulation of atrial natriuretic peptide secretion by serotonin receptor subtypes Cardiovasc Res, August 1, 2003; 59(2): 360 - 368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-W. Fu and J. C Longhurst Activated platelets contribute to stimulation of cardiac afferents during ischaemia in cats: role of 5-HT3 receptors J. Physiol., November 1, 2002; 544(3): 897 - 912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kanaya, H. Ikeda, N. Haramaki, T. Murohara, and T. Imaizumi Intraplatelet Tetrahydrobiopterin Plays an Important Role in Regulating Canine Coronary Arterial Thrombosis by Modulating Intraplatelet Nitric Oxide and Superoxide Generation Circulation, November 13, 2001; 104(20): 2478 - 2484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kawano, H. Tsuji, H. Nishimura, S. Kimura, S. Yano, N. Ukimura, Y. Kunieda, M. Yoshizumi, T. Sugano, K. Nakagawa, et al. Serotonin induces the expression of tissue factor and plasminogen activator inhibitor-1 in cultured rat aortic endothelial cells Blood, March 15, 2001; 97(6): 1697 - 1702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ito, U. Ikeda, M. Shimpo, K. Yamamoto, and K. Shimada Serotonin Increases Interleukin-6 Synthesis in Human Vascular Smooth Muscle Cells Circulation, November 14, 2000; 102(20): 2522 - 2527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. P. Rentrop Thrombi in Acute Coronary Syndromes : Revisited and Revised Circulation, April 4, 2000; 101(13): 1619 - 1626. [Full Text] [PDF]
|
|
|
|
|
|
K. Vikenes, M. Farstad, and J. E. Nordrehaug Serotonin Is Associated with Coronary Artery Disease and Cardiac Events Circulation, August 3, 1999; 100(5): 483 - 489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Eguchi, H. Ikeda, T. Murohara, H. Yasukawa, N. Haramaki, S. Sakisaka, and T. Imaizumi Endothelial Injuries of Coronary Arteries Distal to Thrombotic Sites : Role of Adhesive Interaction Between Endothelial P-Selectin and Leukocyte Sialyl LewisX Circ. Res., March 19, 1999; 84(5): 525 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Musselman, D. L. Evans, and C. B. Nemeroff The Relationship of Depression to Cardiovascular Disease: Epidemiology, Biology, and Treatment Arch Gen Psychiatry, July 1, 1998; 55(7): 580 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Willerson Inhibitors of Platelet Glycoprotein IIb/IIIa Receptors: Will They Be Useful When Given Chronically? Circulation, September 1, 1996; 94(5): 866 - 868. [Full Text]
|
|
|
|
|
|
V. B. Schini-Kerth, B. Fisslthaler, E. Van Obberghen-Schilling, and R. Busse Serotonin Stimulates the Expression of Thrombin Receptors in Cultured Vascular Smooth Muscle Cells : Role of Protein Kinase C and Protein Tyrosine Kinases Circulation, June 15, 1996; 93(12): 2170 - 2177. [Abstract] [Full Text]
|
|
|
|
|
|
N. Maalej and J. D. Folts Increased Shear Stress Overcomes the Antithrombotic Platelet Inhibitory Effect of Aspirin in Stenosed Dog Coronary Arteries Circulation, March 15, 1996; 93(6): 1201 - 1205. [Abstract] [Full Text]
|
|
|
|
|
|
H. W. Mueller, C. A. Haught, J. M. McNatt, K. Cui, S. J. Gaskell, D. A. Johnston, and J. T. Willerson Measurement of Platelet-Activating Factor in a Canine Model of Coronary Thrombosis and in Endarterectomy Samples From Patients With Advanced Coronary Artery Disease Circ. Res., July 1, 1995; 77(1): 54 - 63. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. Golino, F. Piscione, C. R. Benedict, H. V. Anderson, M. Cappelli-Bigazzi, C. Indolfi, M. Condorelli, M. Chiariello, and J. T. Willerson Local Effect of Serotonin Released during Coronary Angioplasty N. Engl. J. Med., February 24, 1994; 330(8): 523 - 528. [Abstract] [Full Text]
|
|