Circulation, Vol 73, 586-595, Copyright © 1986 by American Heart Association
DA Kass, T Yamazaki, D Burkhoff, WL Maughan and K Sagawa
Using a multielectrode conductance catheter to estimate continuous left
ventricular volume we determined the end-systolic pressure-volume
relationship (ESPVR) in situ in open-chest anesthetized dogs. Dogs (n = 8)
were studied in the control state and after pharmacologic sympathectomy
(hexamethonium) and surgical vagotomy both before and after the
administration of dobutamine. ESPVR was measured during brief (5 to 6 sec)
preload reduction by balloon occlusion of the inferior vena cava (IVCBO).
The relationship was highly reproducible. The slope (Ecs) and volume
intercept (Vo) (mean +/- SD) in the control series were 5.8 +/- 3.6 mm
Hg/ml and 6.5 +/- 12.5 ml, respectively. Upon release of the IVCBO (preload
recovery), Ecs was 7.7 +/- 3.6 mm Hg/ml and Vo was 12.4 +/- 9.6 ml (p less
than .01). Autonomic blockade produced a 50% reduction in Ecs and a
concomitant decrease in Vo (p less than .01), and eliminated the difference
between ESPVR generated by preload reduction (IVCBO) and preload recovery
(IVCBO release). Subsequent dobutamine infusion increased Ecs to 6.1 +/-
3.5 mm Hg/ml and Vo to 4.1 +/- 6.9 ml, consistent with reported changes of
the ESPVR with positive inotropic intervention. A small artifact of right
ventricular filling was observed in the left ventricular volume catheter
signal, but this did not appreciably alter the ESPVR. These results
demonstrate the feasibility of the determination of ESPVR in situ by the
conductance catheter and brief IVCBO and underline the importance of the
use of rapid load changes to minimize reflex activation during the
measurements.
ARTICLES
Determination of left ventricular end-systolic pressure-volume relationships by the conductance (volume) catheter technique
This article has been cited by other articles:
 |
|
 |
|
  M. Krenz Conductance, admittance, and hypertonic saline: should we take ventricular volume measurements with a grain of salt? J Appl Physiol, December 1, 2009; 107(6): 1683 - 1684. [Full Text] [PDF]
|
|
|
|
 |
|
 B. Yoo, A. Lemaire, S. Mangmool, M. J. Wolf, A. Curcio, L. Mao, and H. A. Rockman {beta}1-Adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction Am J Physiol Heart Circ Physiol, October 1, 2009; 297(4): H1377 - H1386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Radovits, S. Korkmaz, S. Loganathan, E. Barnucz, T. Bomicke, R. Arif, M. Karck, and G. Szabo Comparative investigation of the left ventricular pressure-volume relationship in rat models of type 1 and type 2 diabetes mellitus Am J Physiol Heart Circ Physiol, July 1, 2009; 297(1): H125 - H133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Shioura, D. L. Geenen, and P. H. Goldspink Sex-related changes in cardiac function following myocardial infarction in mice Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R528 - R534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Notomi, Z. B. Popovic, H. Yamada, D. W. Wallick, M. G. Martin, S. J. Oryszak, T. Shiota, N. L. Greenberg, and J. D. Thomas Ventricular untwisting: a temporal link between left ventricular relaxation and suction Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H505 - H513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Dunaway, Qianli Yu, and D. F. Larson Effect of acute alpha adrenergic stimulation on cardiac function Perfusion, July 1, 2007; 22(4): 289 - 292. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Sidi, J. D. Muehlschlegel, D. S. Kirby, and E. B. Lobato Treatment of ischaemic left ventricular dysfunction with milrinone or dobutamine administered during coronary artery stenosis in the presence of beta blockade in pigs Br. J. Anaesth., December 1, 2006; 97(6): 799 - 807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cannesson, D. Jacques, M. R. Pinsky, and J. Gorcsan III Effects of modulation of left ventricular contractile state and loading conditions on tissue Doppler myocardial performance index Am J Physiol Heart Circ Physiol, May 1, 2006; 290(5): H1952 - H1959. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Disruption of the ventricular myocardial force-frequency relationship after cardiac surgery in children: noninvasive assessment by means of tissue Doppler imaging. J. Thorac. Cardiovasc. Surg., March 1, 2006; 131(3): 625 - 631.
|
|
|
|
 |
|
 T. Katori, D. B. Hoover, J. L. Ardell, R. H. Helm, D. F. Belardi, C. G. Tocchetti, P. R. Forfia, D. A. Kass, and N. Paolocci Calcitonin Gene-Related Peptide In Vivo Positive Inotropy Is Attributable to Regional Sympatho-Stimulation and Is Blunted in Congestive Heart Failure Circ. Res., February 4, 2005; 96(2): 234 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Jacques, M. R. Pinsky, D. Severyn, and J. Gorcsan III Influence of Alterations in Loading on Mitral Annular Velocity by Tissue Doppler Echocardiography and Its Associated Ability To Predict Filling Pressures Chest, December 1, 2004; 126(6): 1910 - 1918. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Grieve, A. C. Cave, J. A. Byrne, J. Layland, and A. M. Shah Analysis of ex vivo left ventricular pressure-volume relations in the isolated murine ejecting heart Exp Physiol, September 1, 2004; 89(5): 573 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Steendijk, S. A.F. Tulner, M. Wiemer, R. A. Bleasdale, J. J. Bax, E. E. van der Wall, J. Vogt, and M. J. Schalij Pressure-volume measurements by conductance catheter during cardiac resynchronization therapy Eur. Heart J. Suppl., August 1, 2004; 6(suppl_D): D35 - D42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Tao and E. R. Sherwood {beta}2-Microglobulin knockout mice treated with anti-asialoGM1 exhibit improved hemodynamics and cardiac contractile function during acute intra-abdominal sepsis Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2004; 286(3): R569 - R575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Pilla, A. S. Blom, D. J. Brockman, V. A. Ferrari, Q. Yuan, and M. A. Acker Passive ventricular constraint to improve left ventricular function and mechanics in an ovine model of heart failure secondary to acute myocardial infarction J. Thorac. Cardiovasc. Surg., November 1, 2003; 126(5): 1467 - 1475. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ohtsuka, K. Ishikawa, S. Suzuki, I. Yamaguchi, N. Masuda, K. Wada, and W. Uchid A porcine model of ischemic heart failure produced by chronic placement of a tube in a coronary artery Eur J Heart Fail, October 1, 2003; 5(5): 591 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. N. Simantirakis, G. E. Kochiadakis, K. E. Vardakis, N. E. Igoumenidis, S. I. Chrysostomakis, and P. E. Vardas Left Ventricular Mechanics and Myocardial Blood Flow Following Restoration of Normal Activation Sequence in Paced Patients With Long-term Right Ventricular Apical Stimulation Chest, July 1, 2003; 124(1): 233 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Segers, V. Tchana-Sato, H. A. Leather, B. Lambermont, A. Ghuysen, J.-M. Dogne, P. Benoit, P. Morimont, P. F. Wouters, P. Verdonck, et al. Determinants of left ventricular preload-adjusted maximal power Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2295 - H2301. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Nozaki, H. Kitahata, K. Tanaka, S. Kawahito, and S. Oshita The Effects of Acute Normovolemic Hemodilution on Left Ventricular Systolic and Diastolic Function in the Absence or Presence of {beta}-Adrenergic Blockade in Dogs Anesth. Analg., May 1, 2002; 94(5): 1120 - 1126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Senzaki, C.-H. Chen, S. Masutani, M. Taketazu, J. Kobayashi, T. Kobayashi, N. Sasaki, H. Asano, S. Kyo, and Y. Yokote Assessment of cardiovascular dynamics by pressure-area relations in pediatric patients with congenital heart disease J. Thorac. Cardiovasc. Surg., September 1, 2001; 122(3): 535 - 547. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Kornet, J.J. Schreuder, E.T. van der Velde, and J.R.C. Jansen The volume-dependency of parallel conductance throughout the cardiac cycle and its consequence for volume estimation of the left ventricle in patients Cardiovasc Res, September 1, 2001; 51(4): 729 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Steendijk, E. Staal, J. W. Jukema, and J. Baan Hypertonic saline method accurately determines parallel conductance for dual-field conductance catheter Am J Physiol Heart Circ Physiol, August 1, 2001; 281(2): H755 - H763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Y. Denault, J. Gorcsan III, and M. R. Pinsky Dynamic effects of positive-pressure ventilation on canine left ventricular pressure-volume relations J Appl Physiol, July 1, 2001; 91(1): 298 - 308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Suehiro, J. Shimizu, G.-H. Yi, S.-M. Zhu, A. Gu, R. R. Sciacca, J. Wang, and D. Burkhoff Direct coronary artery perfusion from the left ventricle J. Thorac. Cardiovasc. Surg., February 1, 2001; 121(2): 0307 - 315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S Hayward, W. V Kalnins, and R. P Kelly Gender-related differences in left ventricular chamber function Cardiovasc Res, February 1, 2001; 49(2): 340 - 350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Leite-Moreira and J. Correia-Pinto Load as an acute determinant of end-diastolic pressure-volume relation Am J Physiol Heart Circ Physiol, January 1, 2001; 280(1): H51 - H59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Kornet, J.J Schreuder, E.T van der Velde, J Baan, and J.R.C Jansen A new approach to determine parallel conductance for left ventricular volume measurements Cardiovasc Res, December 1, 2000; 48(3): 455 - 463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Hayward, W. V. Kalnins, and R. P. Kelly Acute effects of 17beta -estradiol on ventricular and vascular hemodynamics in postmenopausal women Am J Physiol Heart Circ Physiol, November 1, 2000; 279(5): H2277 - H2284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Shishido, K. Hayashi, K. Shigemi, T. Sato, M. Sugimachi, and K. Sunagawa Single-Beat Estimation of End-Systolic Elastance Using Bilinearly Approximated Time-Varying Elastance Curve Circulation, October 17, 2000; 102(16): 1983 - 1989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Feldman, Y. Mao, J. W. Valvano, J. A. Pearce, and G. L. Freeman Development of a multifrequency conductance catheter-based system to determine LV function in mice Am J Physiol Heart Circ Physiol, September 1, 2000; 279(3): H1411 - H1420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Georgakopoulos and D. A. Kass Estimation of parallel conductance by dual-frequency conductance catheter in mice Am J Physiol Heart Circ Physiol, July 1, 2000; 279(1): H443 - H450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. P. Elvenes, C. Korvald, L. M. Ytrebo, O. Irtun, T. Myrmel, T. S. Larsen, and D. Sorlie Myocardial metabolism and efficiency after warm continuous blood cardioplegia Ann. Thorac. Surg., June 1, 2000; 69(6): 1799 - 1805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Patel, J. J. Pilla, D. J. Polidori, S. V. Pusca, T. A. Plappert, M. S. J. Sutton, E. B. Lankford, and M. A. Acker TEN WEEKS OF RAPID VENTRICULAR PACING CREATES A LONG-TERM MODEL OF LEFT VENTRICULAR DYSFUNCTION J. Thorac. Cardiovasc. Surg., April 1, 2000; 119(4): 834 - 841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Korvald, O. P. Elvenes, and T. Myrmel Myocardial substrate metabolism influences left ventricular energetics in vivo Am J Physiol Heart Circ Physiol, April 1, 2000; 278(4): H1345 - H1351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Baretti, A. Mizuno, G. D. Buckberg, and J. S. Child Batista procedure: elliptical modeling against spherical distention Eur. J. Cardiothorac. Surg., January 1, 2000; 17(1): 52 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Yang, D. F. Larson, and R. Watson Age-related left ventricular function in the mouse: analysis based on in vivo pressure-volume relationships Am J Physiol Heart Circ Physiol, November 1, 1999; 277(5): H1906 - H1913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. E. G. Ekelund, R. W. Harrison, O. Shokek, R. N. Thakkar, R. S. Tunin, H. Senzaki, D. A. Kass, E. Marban, and J. M. Hare Intravenous Allopurinol Decreases Myocardial Oxygen Consumption and Increases Mechanical Efficiency in Dogs With Pacing-Induced Heart Failure Circ. Res., September 3, 1999; 85(5): 437 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Leite-Moreira, J. Correia-Pinto, and T. C. Gillebert Afterload induced changes in myocardial relaxation: A mechanism for diastolic dysfunction Cardiovasc Res, August 1, 1999; 43(2): 344 - 353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Loh, E. B. Lankford, D. J. Polidori, E. B. Doering-Lubit, C. W. Hanson, and M. A. Acker Cardiovascular effects of inhaled nitric oxide in a canine model of cardiomyopathy Ann. Thorac. Surg., May 1, 1999; 67(5): 1380 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Korvald, O. P. Elvenes, L. M. Ytrebo, D. G. Sorlie, and T. Myrmel Oxygen-wasting effect of inotropy in the "virtual work model" Am J Physiol Heart Circ Physiol, April 1, 1999; 276(4): H1339 - H1345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-H. Chen, M. Nakayama, E. Nevo, B. J. Fetics, W. L. Maughan, and D. A. Kass Coupled systolic-ventricular and vascular stiffening with age: Implications for pressure regulation and cardiac reserve in the elderly J. Am. Coll. Cardiol., November 1, 1998; 32(5): 1221 - 1227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Banerjee, A. M. Mendelsohn, T. K. Knilans, R. A. Meyer, and D. C. Schwartz Effect of myocardial hypertrophy on systolic and diastolic function in children: insights from the force-frequency and relaxation-frequency relationships J. Am. Coll. Cardiol., October 1, 1998; 32(4): 1088 - 1095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Szwarc and H. A. Ball Simultaneous LV and RV volumes by conductance catheter: effects of lung insufflation on parallel conductance Am J Physiol Heart Circ Physiol, August 1, 1998; 275(2): H653 - H661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Caspi, J. G. Coles, L. N. Benson, and G. J. Wilson Brain Damage and Myocardial Dysfunction: Protective Effects of Magnesium in the Newborn Pig Ann. Thorac. Surg., June 1, 1998; 65(6): 1730 - 1736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A White, C. I.O Brookes, H. B Ravn, E. E Stenbog, T. D Christensen, R. R Chaturvedi, K. Sorensen, V. E Hjortdal, and A. N Redington The effect of changing excitation frequency on parallel conductance in different sized hearts Cardiovasc Res, June 1, 1998; 38(3): 668 - 675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Uozaki, A. Murakami, H. Asanoi, S. Ishizaka, and T. Misaki Effect of Assisted Circulation on Left Ventricular Performance in a Canine Model Ann. Thorac. Surg., March 1, 1998; 65(3): 663 - 666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Chaturvedi, C. Lincoln, J. W. W. Gothard, M. H. Scallan, P. A. White, A. N. Redington, and D. F. Shore Left ventricular dysfunction after open repair of simple congenital heart defects in infants and children: Quantitation with the use of a conductance catheter immediately after bypass J. Thorac. Cardiovasc. Surg., January 1, 1998; 115(1): 77 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Fraites Jr, A. Saeki, and D. A. Kass Effect of Altering Filling Pattern on Diastolic Pressure-Volume Curve Circulation, December 16, 1997; 96(12): 4408 - 4414. [Abstract] [Full Text]
|
|
|
|
|
|
H. J. Patel, D. J. Polidori, J. J. Pilla, T. Plappert, D. Kass, M. S. J. Sutton, E. B. Lankford, and M. A. Acker Stabilization of Chronic Remodeling by Asynchronous Cardiomyoplasty in Dilated Cardiomyopathy : Effects of a Conditioned Muscle Wrap Circulation, November 18, 1997; 96(10): 3665 - 3671. [Abstract] [Full Text]
|
|
|
|
|
|
H. J. Patel, E. B. Lankford, D. J. Polidori, J. J. Pilla, T. Plappert, M. St. J. Sutton, and M. A. Acker DYNAMIC CARDIOMYOPLASTY: ITS CHRONIC AND ACUTE EFFECTS ON THE FAILING HEART J. Thorac. Cardiovasc. Surg., August 1, 1997; 114(2): 169 - 178. [Abstract] [Full Text]
|
|
|
|
|
|
T. C. Gillebert, A. F. Leite-Moreira, and S. G. De Hert Relaxation–Systolic Pressure Relation: A Load-Independent Assessment of Left Ventricular Contractility Circulation, February 4, 1997; 95(3): 745 - 752. [Abstract] [Full Text]
|
|
|
|
|
|
M. M. R. Amirhamzeh, D. A. Dean, C.-X. Jia, S. E. Cabreriza, O. J. Yano, D. Burkhoff, and H. M. Spotnitz Validation of Right and Left Ventricular Conductance and Echocardiography for Cardiac Function Studies Ann. Thorac. Surg., October 1, 1996; 62(4): 1104 - 1109. [Abstract] [Full Text]
|
|
|
|
|
|
F. V. DiPierro, J. E. Bavaria, E. B. Lankford, D. J. Polidori, M. A. Acker, J. T. Streicher, and T. J. Gardner Triiodothyronine Optimizes Sheep Ventriculoarterial Coupling for Work Efficiency Ann. Thorac. Surg., September 1, 1996; 62(3): 662 - 669. [Abstract] [Full Text]
|
|
|
|
|
|
A. C. Nicolosi, D. A. Hettrick, and D. C. Warltier Assessment of Right Ventricular Function in Swine Using Sonomicrometry and Conductance Ann. Thorac. Surg., May 1, 1996; 61(5): 1381 - 1387. [Abstract] [Full Text]
|
|
|
|
|
|
D. A. Kass, A. Saeki, R. S. Tunin, and F. A. Recchia Adverse Influence of Systemic Vascular Stiffening on Cardiac Dysfunction and Adaptation to Acute Coronary Occlusion Circulation, April 15, 1996; 93(8): 1533 - 1541. [Abstract] [Full Text]
|
|
|
|
|
|
S. Ishizaka, H. Asanoi, O. Wada, T. Kameyama, and H. Inoue Loading Sequence Plays an Important Role in Enhanced Load Sensitivity of Left Ventricular Relaxation in Conscious Dogs With Tachycardia-Induced Cardiomyopathy Circulation, December 15, 1995; 92(12): 3560 - 3567. [Abstract] [Full Text]
|
|
|
|
|
|
O. Kawaguchi, W. E. Pae, W. B. Daily, J. S. Sapirstein, and W. S. Pierce Left ventricular mechanoenergetics during asynchronous left atrial-to-aortic bypass: Effects of pumping rate on cardiac workload and myocardial oxygen consumption J. Thorac. Cardiovasc. Surg., September 1, 1995; 110(3): 793 - 799. [Abstract] [Full Text]
|
|
|
|
|
|
M. Oe, J. Gorcsan III, W. A. Mandarino, A. Kawai, B. P. Griffith, and R. L. Kormos Automated Echocardiographic Measures of Right Ventricular Area as an Index of Volume and End-Systolic Pressure-Area Relations to Assess Right Ventricular Function Circulation, August 15, 1995; 92(4): 1026 - 1033. [Abstract] [Full Text]
|
|
|
|
|
|
R. D. Berger, M. R. Wolff, J. H. Anderson, and D. A. Kass Role of Atrial Contraction in Diastolic Pressure Elevation Induced by Rapid Pacing of Hypertrophied Canine Ventricle Circ. Res., July 1, 1995; 77(1): 163 - 173. [Abstract] [Full Text]
|
|
|
|
|
|
O. Kawaguchi, J. S. Sapirstein, W. B. Daily, W. E. Pae, and W. S. Pierce Linear end-systolic pressure-volume relationship during pulsatile left ventricular bypass represents native heart function J. Thorac. Cardiovasc. Surg., April 1, 1995; 109(4): 780 - 786. [Abstract] [Full Text]
|
|
|
|
|
|
A. Saeki, F. Recchia, and D. A. Kass Systolic Flow Augmentation in Hearts Ejecting Into a Model of Stiff Aging Vasculature : Influence on Myocardial Perfusion-Demand Balance Circ. Res., January 1, 1995; 76(1): 132 - 141. [Abstract] [Full Text]
|
|
|
|
|
|
O. Kawaguchi, J. S. Sapirstein, W. B. Daily, W. E. Pae, and W. S. Pierce Left ventricular mechanics during synchronous left atrial-aortic bypass J. Thorac. Cardiovasc. Surg., June 1, 1994; 107(6): 1503 - 1511. [Abstract] [Full Text]
|
|