This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wallmeyer, K. Articles by Klopfenstein, H. S. Search for Related Content PubMed PubMed Citation Articles by Wallmeyer, K. Articles by Klopfenstein, H. S. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB NITROGLYCERIN PROPRANOLOL HYDROCHLORIDE

Circulation, Vol 74, 181-186, Copyright © 1986 by American Heart Association

ARTICLES

The influence of preload and heart rate on Doppler echocardiographic indexes of left ventricular performance: comparison with invasive indexes in an experimental preparation

K Wallmeyer, LS Wann, KB Sagar, J Kalbfleisch and HS Klopfenstein

We evaluated the ability of Doppler echocardiography to assess left ventricular performance in six open-chest dogs studied under various conditions. Intravenous infusions of nitroglycerin were used to vary preload, atrial pacing was used to control heart rate, and changes in inotropic state were induced by two different doses of dobutamine (5 and 10 micrograms/kg/min iv) and by administration of propranolol (1 mg/kg iv). Left ventricular anterior wall myocardial segment length was used as an index of preload. Maximum aortic blood flow, peak acceleration of aortic blood flow, and dP/dt were measured with an electromagnetic flow probe around the ascending aorta and a high- fidelity pressure transducer in the left ventricle. A continuous-wave Doppler transducer applied to the aortic arch was used to measure peak aortic blood velocity, mean acceleration, time to peak velocity, and the systolic velocity integral. The differences between mean values obtained under different inotropic conditions were significant at the p less than .01 level for peak velocity and at the p less than .05 level for mean acceleration. Within a given animal, Doppler measurements of peak velocity correlated very closely with maximum aortic flow (r = .96), maximum acceleration of aortic flow (r = .95), and with maximum dP/dt (r = .92). Mean acceleration measured by Doppler echocardiography also correlated very closely with conventional indexes, but was subject to greater interobserver variability. Doppler measurements of time to peak and the systolic velocity integral correlated less well with conventional hemodynamic indexes.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				A. L. Raisis, K. J. Blissitt, W. Henley, K. Rogers, V. Adams, and L. E. Young The effects of halothane and isoflurane on cardiovascular function in laterally recumbent horses Br. J. Anaesth., September 1, 2005; 95(3): 317 - 325. [Abstract] [Full Text] [PDF]

				C. K. L. Phoon and D. H. Turnbull Ultrasound biomicroscopy-Doppler in mouse cardiovascular development Physiol Genomics, June 24, 2003; 14(1): 3 - 15. [Abstract] [Full Text] [PDF]

				F. Bauer, M. Jones, T. Shiota, M. S. Firstenberg, J. X. Qin, H. Tsujino, Y. J. Kim, M. Sitges, L. A. Cardon, A. D. Zetts, et al. Left ventricular outflow tract mean systolic acceleration as a surrogatefor the slope of the left ventricular end-systolic pressure-volume relationship J. Am. Coll. Cardiol., October 2, 2002; 40(7): 1320 - 1327. [Abstract] [Full Text] [PDF]

				A. Nakamura, D. G. Rokosh, M. Paccanaro, R. R. Yee, P. C. Simpson, W. Grossman, and E. Foster LV systolic performance improves with development of hypertrophy after transverse aortic constriction in mice Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1104 - H1112. [Abstract] [Full Text] [PDF]

				C. J. DiCorte, P. Latham, P. E. Greilich, M. V. Cooley, P. A. Grayburn, and M. E. Jessen Esophageal Doppler monitor determinations of cardiac output and preload during cardiac operations Ann. Thorac. Surg., June 1, 2000; 69(6): 1782 - 1786. [Abstract] [Full Text] [PDF]

				P. E. Marik Pulmonary Artery Catheterization and Esophageal Doppler Monitoring in the ICU Chest, October 1, 1999; 116(4): 1085 - 1091. [Abstract] [Full Text] [PDF]

				E. Mousseaux, J. P. Tasu, O. Jolivet, G. Simonneau, J. Bittoun, and J.-C. Gaux Pulmonary Arterial Resistance: Noninvasive Measurement with Indexes of Pulmonary Flow Estimated at Velocity-encoded MR Imaging-Preliminary Experience Radiology, September 1, 1999; 212(3): 896 - 902. [Abstract] [Full Text]

				M. V. Sherrid, G. Pearle, and D. Z. Gunsburg Mechanism of Benefit of Negative Inotropes in Obstructive Hypertrophic Cardiomyopathy Circulation, January 13, 1998; 97(1): 41 - 47. [Abstract] [Full Text] [PDF]

				B. D. Hoit, S. F. Khoury, E. G. Kranias, N. Ball, and R. A. Walsh In Vivo Echocardiographic Detection of Enhanced Left Ventricular Function in Gene-Targeted Mice With Phospholamban Deficiency Circ. Res., September 1, 1995; 77(3): 632 - 637. [Abstract] [Full Text]