Circulation, Vol 74, 939-944, Copyright © 1986 by American Heart Association
R Rauramaa, JT Salonen, K Seppanen, R Salonen, JM Venalainen, M Ihanainen and V Rissanen
It has been postulated that platelet function plays an important role in
the initiation of atherosclerosis. Currently there are no definitive data
on the longer-term effects of regular physical exercise on platelet
function in humans. We assessed the influence of regular moderate-intensity
physical exercise (brisk walking to slow jogging) on platelet aggregation
in a population-based sample of middle-aged, overweight, mildly
hypertensive men in eastern Finland. In this controlled study, we evaluated
the net effect of exercise on platelet aggregation by studying changes in
optical density and ATP release in platelet-rich plasma. A significant
inhibition of secondary platelet aggregation from 27% to 36% was observed
in the men taking regular exercise. These findings give new insight into
the possible protective effects of exercise against the risk of ischemic
heart disease.
ARTICLES
Inhibition of platelet aggregability by moderate-intensity physical exercise: a randomized clinical trial in overweight men
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