Circulation, Vol 75, 627-635, Copyright © 1987 by American Heart Association
FI Faruqui, MD Otten and PI Polimeni
The inhibitory effect of Separan AP-30, an anionic polyacrylamide, on
atherosclerotic plaque formation in aortas of rabbits on a high (2%)
cholesterol diet was tested over a period extending from 37 to 170 days.
Atherogenesis was quantified morphometrically by application of a
computer-assisted image analysis of histologic cross sections of the aorta.
The area of vessel wall-atheroma interface, fraction of lumen occluded, and
other indexes of atherogenesis were measured in each of 26 segments of
aorta excised from the animals, half of which were administered injections
(intravenous) of Separan three times a week. Regression analysis of the
morphometric data indicates that the polyelectrolyte exerts a powerful
antiatherogenic effect in all regions of the aorta, inhibiting the
formation of plaque mass to less than half in the aortic arch and about
one-fifth in the descending aorta as compared with the aortic plaque masses
in untreated rabbits. Results are compatible with the suggestion that a
novel hemodynamic principle in vivo, polymer drag reduction, might be
effectively applied against atherosclerosis.
ARTICLES
Protection against atherogenesis with the polymer drag-reducing agent Separan AP-30
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