Circulation, Vol 75, 636-642, Copyright © 1987 by American Heart Association
JR Wilentz, TA Sanborn, CC Haudenschild, CR Valeri, TJ Ryan and DP Faxon
Since platelet accumulation may be an important determinant of restenosis
after angioplasty, the time course of 51Cr-labeled platelet accumulation
after experimental angioplasty was evaluated in a deendothelialized,
hypercholesterolemic rabbit preparation of atherosclerosis. Marked platelet
accumulation (39.5 +/- 8.7 X 10(6) platelets/1 cm vessel length) was
observed at 30 min and remained active until 4 hr after angioplasty. Total
accumulation over 24 hr was 56.4 +/- 4.7 X 10(6) platelets/1 cm length.
Histologic dissection was directly related to the degree of platelet
accumulation, with 64 +/- 15 X 10(6) platelets/1 cm in the group with
marked dissection and 8.7 +/- 3.7 X 10(6) platelets/1 cm in the group with
minimal dissection (p less than .05). Increasing angiographic dissection
also resulted in a trend toward increased platelet accumulation, and
angiographic change in luminal diameter showed a significant correlation
with platelet accumulation. It is concluded that marked platelet
accumulation occurs early after transluminal angioplasty and is related to
the extent of dissection. Restenosis may result from a complex interaction
of platelet accumulation, vascular damage, and blood flow.
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Platelet accumulation in experimental angioplasty: time course and relation to vascular injury
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