Circulation, Vol 76, 891-897, Copyright © 1987 by American Heart Association
GS Roubin, KA Robinson, SB King 3d, C Gianturco, AJ Black, JE Brown, RJ Siegel and JS Douglas Jr
Intimal dissection with acute closure represents the major complication
associated with percutaneous transluminal coronary angioplasty (PTCA).
Intracoronary stent devices offer the possibility of treatment for this
sequela. We developed a balloon catheter-mounted, flexible coil stent for
use in such cases. To determine the utility of this device and its
immediate and long-term influence on arterial patency, 39 mongrel dogs had
the stent placed after PTCA of the left circumflex or left anterior
descending coronary arteries. Thirteen animals were treated before and
after the procedure with warfarin. In this group there were three early
deaths associated with stent thrombosis. Twenty-six animals were
subsequently treated before and after with aspirin and dipyridamole. There
were no early thrombotic events associated with stent placement in these
animals. Late arteriographic examination revealed patent vessels in all
dogs. Diameter stenosis for warfarin-treated dogs was 8 +/- 5% (mean +/-
SD) at 2 months (n = 9), 6 +/- 4% at 6 months (n = 5), and 11 +/- 7% at 12
months (n = 3). Diameter stenosis for aspirin/dipyridamole-treated dogs was
9 +/- 3% at 2 months (n = 8), 8 +/- 5% at 6 months (n = 12), and 5% at 12
months (n = 1). Light and scanning electron microscopic analyses of stented
arteries demonstrated incorporation of the stent wires into the arterial
wall. Early findings included mild thrombosis localized to areas of wire
entrenchment followed by rapid regrowth of endothelial and/or
pseudoendothelial cells over trenches, exposed wires, and
elastica.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Early and late results of intracoronary arterial stenting after coronary angioplasty in dogs
Andreas Gruentzig Cardiovascular Center, Emory University Hospital, Atlanta, GA 30322.
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