Circulation, Vol 76, 1262-1273, Copyright © 1987 by American Heart Association
CJ Wolfkiel, JL Ferguson, EV Chomka, WR Law, IN Labin, ML Tenzer, M Booker and BH Brundage
Myocardial blood flow was analyzed by radioisotope-labeled microspheres and
ultrafast computed tomography (CT) in 16 closed-chest, anesthetized dogs.
The first set of 10 dogs had CT and microsphere measurements before and
after chromonar-induced increases in myocardial blood flow. A second set of
six dogs had flows measured at control and during temporary reductions in
regional flow produced by balloon cuff occlusion of the left anterior
descending coronary artery. All dogs had four-slice, 20-instance CT scans
after injection of a medium bolus (0.35 ml/kg) of contrast medium into a
femoral vein simultaneous with injection of microspheres into the left
atrium. CT myocardial flow was calculated as the change in myocardial CT
numbers divided by the area from a blood pool time-density curve. A wide
range of myocardial blood flows was produced as determined by microspheres
(0 to 6.7 ml/min/g). Global flow of the first set of dogs was shown to have
excellent correlation (r = .95, n = 17) for a limited range (.4 less than X
less than 1.4 ml/min/g) of flows. Regional flows of these measurements
demonstrated less correlation (r = .63, n = 110) but extended the range of
flow to 1.7 ml/min/g. At higher flows (greater than 2.5 ml/min/g) the
correlation for global and regional flows was not significantly different
than zero. Regional ischemic flow correlation extended the linear range of
flow to 0 ml/min/g (r = .62, n = 17). These results show that CT can
measure myocardial blood flow over a limited but clinically relevant range
of flows defined as slightly above normal to ischemic. These results
indicate that another preparation of CT flow measurement must be sought for
quantification of myocardial perfusion values significantly above normal.
ARTICLES
Measurement of myocardial blood flow by ultrafast computed tomography
Department of Medicine, University of Illinois College of Medicine at Chicago 60680.
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